2. 天然产物
  3. 植物 甾体类
  4. 夹竹桃科 强心苷类
  5. 黄花夹竹桃
  6. 阔叶竹桃
  7. Evomonoside

Evomonoside 是一种强心苷类化合物。Evomonoside 展现出显著的体外抗癌活性，特别是对胃癌细胞系具有纳摩尔级别的抑制浓度。Evomonoside 具有典型的心脏毒性风险，包括心律失常和传导异常。Evomonoside 可用于研究胃癌。

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Evomonoside

Evomonoside Chemical Structure

CAS No. : 508-93-0

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Evomonoside 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Evomonoside is a type of cardiac glycoside compound. Evomonoside exhibits significant in vitro anticancer activity, especially having nanomolar inhibitory concentrations against gastric cancer cell lines. Evomonoside has typical cardiac toxicity risks, including arrhythmias and conduction abnormalities. Evomonoside can be used for research on gastric cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HFF CC50
0.7 μM
Compound: 3, alpha-L-Rhap-Dig
Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay
Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay
[PMID: 24900847]
HFF CC50
2 μM
Compound: 3, alpha-L-Rhap-Dig
Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay
Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay
[PMID: 24900847]
NCI-H460 IC50
46.7 nM
Compound: 6, alpha-L-rhamnose
Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining
Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining
[PMID: 21643465]
NCI-H460 IC50
47.03 nM
Compound: 4, mono-4
Cytotoxicity against human NCI-H460 cell assessed as cell death after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
Cytotoxicity against human NCI-H460 cell assessed as cell death after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
[PMID: 21660118]
NCI-H460 IC50
51.71 nM
Compound: 4, C5'-Me-4
Induction of apoptosis in human NCI-H460 cells in serum free medium after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
Induction of apoptosis in human NCI-H460 cells in serum free medium after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
[PMID: 21572583]
NCI-H460 IC50
52 nM
Compound: 4, C5'-Me-4
Cytotoxicity in human NCI-H460 cells in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
Cytotoxicity in human NCI-H460 cells in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy
[PMID: 21572583]
分子量

520.65

Formula

C29H44O8
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Evomonoside 相关分类

  • 摩尔计算器

  • 稀释计算器

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Evomonoside508-93-0Otherscardiac glycosidecytotoxicityLepidium apetalumdigitoxigeninanticancer activityInhibitorinhibitorinhibit

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