2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. ADC Payload Topoisomerase
  4. Exatecan hydrochloride

Exatecan hydrochloride  (Synonyms: DX-8951 hydrochloride)

目录号: HY-13631U
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Exatecan (DX-8951) hydrochloride 是一种 DNA 拓扑异构酶 I (topoisomerase I) 抑制剂，IC50 值为 2.2 μM (0.975 μg/mL)，可用于癌症研究。

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CAS No. : 144008-87-7

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Exatecan hydrochloride 的其他形式现货产品:

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Exatecan hydrochloride 相关抗体

Top Publications Citing Use of Products

    Exatecan hydrochloride purchased from MCE. Usage Cited in: Mol Cancer Ther. 2023 Sep 5;22(9):1013-1027.  [Abstract]

    In vivo efficacy of AMT-562, Ab562-T1000-Exatecan (10 mg/kg; i.v.), and P-GGFG-DXd in PC9 xenograft model.

    Exatecan hydrochloride purchased from MCE. Usage Cited in: Mol Cancer Ther. 2023 Sep 5;22(9):1013-1027.  [Abstract]

    In vitro cytotoxicity of Exatecan and DXd in HER3-expressing cells. Cells were incubated with a concentration series of Exatecan or DXd for 5 days. Cell viability was measured by CCK-8 and IC50 for each cell line was calculated from cell viability-concentration plot.

    Exatecan hydrochloride purchased from MCE. Usage Cited in: Mol Cancer Ther. 2023 Sep 5;22(9):1013-1027.  [Abstract]

    Representative hematoxylin and eosin staining of toxicity organs of AMT-562 and Ab562-T1000-Exatecan (ADC; 30 mg/kg; i.v.). Scale bar, 200 mm.

    Exatecan hydrochloride purchased from MCE. Usage Cited in: Mol Cancer Ther. 2023 Sep 5;22(9):1013-1027.  [Abstract]

    Single dose pharmacokinetic profiles of AMT-562 (ADC) and Ab562-GGFG-DXd in mice. ADCs were intravenously administered to mice at the dose of 10 mg/kg.

    Exatecan hydrochloride purchased from MCE. Usage Cited in: Mol Cancer Ther. 2023 Sep 5;22(9):1013-1027.  [Abstract]

    Patient-derived colon cancer organoids response to AMT-562 (ADC) and P-GGFG-DXd. Representative images of brightfield (left) and live/dead cells (right) for CO117 was shown. Colon cancer PDOs were treated with AMT-562 or P-GGFG-DXd at a serial concentration for 6 days. Live cells were stained by Calcein AM (green) and dead cells by PI (red).

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    Topoisomerase Topo I Topo II DNA gyrase

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    Exatecan hydrochloride 相关分类

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    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Exatecan144008-87-7DX-8951DX8951DX 8951ADC PayloadTopoisomeraseADC CytotoxinInhibitorinhibitorinhibit

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