2. GPCR/G Protein Anti-infection
  3. Formyl Peptide Receptor (FPR) Bacterial
  4. f-MKKFRW

f-MKKFRW 是一种选择性鼠犁鼻器感觉神经元 (VSNs) 中甲酰肽受体 3 (Fpr3) 激活剂，同时也是源自细菌 MgrB 的肽基序。f-MKKFRW 可激活 Fpr3，在转染 Fpr3 的 HEK293T 细胞的 EC50 为 7.7 μM，从而在表达 Fpr3 的细胞中触发下游信号传导与钙响应。f-MKKFRW 可刺激副嗅觉系统中的一部分小鼠犁鼻器感觉神经元，引发钙响应。f-MKKFRW 可通过鼻腔接触诱导小鼠产生先天性回避行为。

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Custom Peptide Synthesis

f-MKKFRW

f-MKKFRW Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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f-MKKFRW 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

f-MKKFRW is a selective mouse formyl peptide receptor 3 (Fpr3) activator and bacterial MgrB-derived peptide motif. f-MKKFRW activates Fpr3 to trigger downstream signaling and calcium responses in Fpr3-expressing cells. f-MKKFRW stimulates a subset of mouse vomeronasal sensory neurons in the accessory olfactory system to evoke calcium responses. f-MKKFRW drives innate avoidance behavior in mice via nasal contact[1].

体内研究
(In Vivo)

f-MKKFRW (50-100 μM；局部给药于滤纸片；单次暴露) 可在未接触过该物质的雄性小鼠中诱导依赖 Fpr3、Gαo 和 Trpc2 的先天性躲避行为[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6N (B6) mice (male, 8-14 weeks old); ΔFpr3-lacZ +/+ mice; cGao +/- mice; Trpc2 +/- mice[1]
Dosage: 50 μM; 100 μM
Administration: topical application to filter paper; single exposure
Result: Induced a mean avoidance index of -0.34 in B6 mice, indicating significant avoidance of the peptide-supplemented FEU compared to plain FEU. Showed absent avoidance in ΔFpr3-lacZ -/-, cGao -/-, and Trpc2 -/- mice.
Triggered avoidance behavior at the 50 μM dose.
分子量

923.14

Formula

C44H66N12O8S
Sequence

{fMet}-Lys-Lys-Phe-Arg-Trp
Sequence Shortening

{fMet}-MKKFRW
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

f-MKKFRW 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

f-MKKFRWFormyl Peptide Receptor (FPR)BacterialGaoVSNsFpr3-expressing cellsMgrBmouse formyl peptide receptor 3mouse vomeronasal sensory neuronsHEK293T cellsTrpc2Fpr3accessory olfactory systemInhibitorinhibitorinhibit

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