2. Protein Tyrosine Kinase/RTK Apoptosis
  3. FAK Apoptosis
  4. FAK-IN-29

FAK-IN-29 是一种选择性 FAK 抑制剂，IC50 为 0.5 nM。FAK-IN-29 可抑制 MDA-MB-231 细胞增殖、克隆形成，并诱导细胞周期阻滞和凋亡 (apoptosis)。FAK-IN-29 具有抗肿瘤的活性，可用于三阴性乳腺癌等肿瘤的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

FAK-IN-29

FAK-IN-29 Chemical Structure

CAS No. : 3104566-26-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

FAK-IN-29 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FAK-IN-29 is a selective FAK inhibitor with an IC50 of 0.5 nM. FAK-IN-29 can inhibit the proliferation and colony formation of MDA-MB-231 cells, and induce cell cycle arrest and apoptosis. FAK-IN-29 exhibits antitumor activity and can be used for the research of tumors such as triple-negative breast cancer[1].

体外研究
(In Vitro)

FAK-IN-29 (Compound 7h) (3 μM；24 小时) 在 MDA-MB-231 细胞中诱导 G2/M 期细胞周期阻滞[1]。
FAK-IN-29 (0.15625-50 μM, 48 小时) 对 MDA-MB-231、SKOV3 和 HepG2 细胞的 IC50 分别为 0.18、0.17 和 0.15 μM[1]。
FAK-IN-29 (0.3-3 μM；24 小时) 在 MDA-MB-231 细胞中诱导浓度依赖性凋亡[1]。
FAK-IN-29 (0.3-3 μM；24 小时) 在 MDA-MB-231 细胞中显著抑制克隆形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FAK-IN-29 相关抗体:

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231
Concentration: 3 μM
Incubation Time: 24 h
Result: Caused a significant accumulation of MDA-MB-231 cells in the G2/M phase, with a corresponding decrease in the G0/G1 phase. The G2/M phase population increased from 10.4% to 35.7%, while the G0/G1 phase decreased from 68.3% to 45.2%.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231
Concentration: 0.3, 1, and 3 μM
Incubation Time: 24 h
Result: Induced apoptosis in a concentration-dependent manner. The total apoptotic rates were 5.62 %, 33.15 %, and 62.48 % at concentrations of 0.3, 1, and 3 μM, respectively.
体内研究
(In Vivo)

FAK-IN-29 (5-10 mg/kg，静脉注射, 14 天) 在 MDA-MB-231 肿瘤异种移植裸鼠模型中表现出强效的抗肿瘤活性，并具有良好的安全特性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (MDA-MB-231 tumor xenograft model)[1]
Dosage: 5 mg/kg, 10 mg/kg
Administration: i.v.
Result: Achieved 61.8% tumor growth inhibition in MDA-MB-231 xenograft models, comparable to Paclitaxel (HY-B0015) (54.8%) at 10 mg/kg.
Significantly reduced Tumor volumes in both 5 mg/kg and 10 mg/kg groups.
Caused no observable toxicity, and body weights and organ weights remained stable.
Caused no histopathological abnormalities.
分子量

502.54

Formula

C26H27FN8O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FAK-IN-29 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAK-IN-293104566-26-6FAKApoptosisPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseFocal adhesion kinase (FAK)Triple negative breast cancerMDA-MB-231Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
FAK-IN-29
目录号：
HY-179679
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z