2. Apoptosis Others
  3. Ferroptosis Fluorescent Dye
  4. Ferfluor-1

Ferfluor-1 是一种具有血脑屏障通透性铁死亡 (Ferroptosis) 抑制剂 (HT108 细胞中 EC50 为 57 nM；OS-RC-2 细胞中 EC50 为 75 nM；SH-SY5Y 神经母细胞瘤细胞中 EC50 为 2.3 nM)，同时也是一种比率型光致发光探针。Ferfluor-1 是铁死亡波动的特异性指示剂。Ferfluor-1 可改善脑卒中及 PD 模型的脑部紊乱。

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Ferfluor-1

Ferfluor-1 Chemical Structure

CAS No. : 3030473-59-4

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Ferfluor-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ferfluor-1 is a Ferroptosis inhibitor (EC50 of 57 nM in HT108 cells; EC50 of 75 nM in OS-RC-2 cells; EC50 of 2.3 nM in SH-SY5Y neuroblastoma cells), and ratiometric photoluminescent probe with blood-brain barrier permeability. Ferfluor-1 is a specific indicator for the fluctuation of Ferroptosis. Ferfluor-1 alleviates brain disorder diseases of in vivo stroke and PD models[1].

体外研究
(In Vitro)

Ferfluor-1 可强效抑制 HT1080 纤维肉瘤细胞、OS-RC-2 肾癌细胞及 SH-SY5Y 神经母细胞瘤细胞中的铁死亡，其在上述三种细胞中的 EC50 分别为 57 nM、75 nM 和 2.3 nM[1]。
Ferfluor-1 (5 μM) 不会抑制 Staurosporine (HY-15141) 诱导的 SH-SY5Y 神经母细胞瘤细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ferfluor-1 相关抗体:
体内研究
(In Vivo)

Ferfluor-1 (10 mg/kg；静脉注射) 可通过抑制铁死亡有效减轻 MCAO 小鼠的脑缺血损伤，具体表现为梗死体积减小、脑血流量改善，以及脂质过氧化和铁死亡标志物水平降低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male)[1]
Dosage: 10 mg/kg
Administration: i.v.; single administration
Result: Substantially decreased cerebral infarction volume compared to the vehicle control.
Reduced the proportion of infarcted tissue compared to the vehicle control.
Improved blood flow in ischemic brain tissue compared to the vehicle control.
Significantly decreased PTGS2 gene expression in the lesioned hemisphere compared to the vehicle control.
Reduced malondialdehyde (MDA) levels in the lesioned hemisphere relative to the vehicle control.
Showed no obvious toxicity in major organs (heart, liver, spleen, lung, kidney) via histopathological staining.
分子量

288.41

Formula

C15H20N4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ferfluor-1 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Ferfluor-13030473-59-4Ferfluor1Ferfluor 1FerroptosisFluorescent Dyephospholipid peroxidationOS-RC-2 renal carcinoma cellsferroptosisphospholipid hydroperoxidesParkinson’s diseaseHT1080 fibrosarcoma cellsstrokeblood-brain barrierSH-SY5Y neuroblastoma cellsendoplasmic reticulumInhibitorinhibitorinhibit

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Ferfluor-1
目录号：
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