2. Apoptosis Metabolic Enzyme/Protease
  3. Glutathione Peroxidase Ferroptosis
  4. Ferroptosis-IN-18

Ferroptosis-IN-18 (51) 是一种吩噻嗪衍生物，表现出强烈的抗铁死亡和抗氧化特性。Ferroptosis-IN-18 (51) 可以用于脑内出血 (ICH) 的研究。

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Ferroptosis-IN-18

Ferroptosis-IN-18 Chemical Structure

CAS No. : 2247525-20-6

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Ferroptosis-IN-18 相关抗体

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GPX1 GPX4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ferroptosis-IN-18 (51), a promethazine derivative, shows strong anti-ferroptosis and anti-oxidant properties. Ferroptosis-IN-18 (51) can be used in the research for intracerebral hemorrhage (ICH)[1].

IC50 & Target

GPX4

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
> 10 μM
Compound: 51
Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human A-375 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
BJ IC50
> 10 μM
Compound: 51
Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
BXPC-3 EC50
2.925 nM
Compound: 51
Inhibition of erastin-induced ferroptosis in human BXPC-3 cells assessed as cell viability incubated for 48 hrs by MTT assay
Inhibition of erastin-induced ferroptosis in human BXPC-3 cells assessed as cell viability incubated for 48 hrs by MTT assay
[PMID: 33065375]
Bel-7402 IC50
> 10 μM
Compound: 51
Cytotoxicity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
CHL-1 IC50
> 10 μM
Compound: 51
Cytotoxicity against human CHL-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human CHL-1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
Calu-1 EC50
1.879 nM
Compound: 51
Inhibition of erastin-induced ferroptosis in human Calu-1 cells assessed as cell viability incubated for 48 hrs by MTT assay
Inhibition of erastin-induced ferroptosis in human Calu-1 cells assessed as cell viability incubated for 48 hrs by MTT assay
[PMID: 33065375]
DU-145 IC50
> 10 μM
Compound: 51
Cytotoxicity against human DU-145 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human DU-145 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
HEK-293T IC50
> 10 μM
Compound: 51
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
HT-1080 EC50
0.0005 μM
Compound: 51
Inhibition of erastin-induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 48 hrs by MTT assay
Inhibition of erastin-induced ferroptosis in human HT-1080 cells assessed as cell viability incubated for 48 hrs by MTT assay
[PMID: 33065375]
HUVEC IC50
> 10 μM
Compound: 51
Cytotoxicity against HUVEC assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against HUVEC assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
HaCaT IC50
> 10 μM
Compound: 51
Cytotoxicity against human HaCaT cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HaCaT cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
Huh-7 IC50
> 10 μM
Compound: 51
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
K562 IC50
> 10 μM
Compound: 51
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
L02 IC50
> 10 μM
Compound: 51
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
MDA-MB-231 EC50
0.424 nM
Compound: 51
Inhibition of erastin-induced ferroptosis in human MDA-MB-231 cells assessed as cell viability incubated for 48 hrs by MTT assay
Inhibition of erastin-induced ferroptosis in human MDA-MB-231 cells assessed as cell viability incubated for 48 hrs by MTT assay
[PMID: 33065375]
MDA-MB-231 IC50
> 10 μM
Compound: 51
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
MDA-MB-435 IC50
> 10 μM
Compound: 51
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
Malme-3M IC50
> 10 μM
Compound: 51
Cytotoxicity against human Malme-3M cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human Malme-3M cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
NCI-H1975 IC50
> 10 μM
Compound: 51
Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
NCI-H23 IC50
> 10 μM
Compound: 51
Cytotoxicity against human NCI-H23 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H23 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
PC-9 IC50
> 10 μM
Compound: 51
Cytotoxicity against human PC-9 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human PC-9 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
SK-OV-3 IC50
> 10 μM
Compound: 51
Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
U-251 IC50
> 10 μM
Compound: 51
Cytotoxicity against human U-251 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human U-251 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
U-87MG ATCC IC50
> 10 μM
Compound: 51
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33065375]
体外研究
(In Vitro)

Ferroptosis-IN-18 (51) 增加细胞活力和 GPX4 水平。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ferroptosis-IN-18 相关抗体:
分子量

401.57

Formula

C25H27N3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ferroptosis-IN-18 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferroptosis-IN-182247525-20-6Glutathione PeroxidaseFerroptosisanti-oxidantICHInhibitorinhibitorinhibit

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