2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS)
  4. Ferroptosis-IN-23

Ferroptosis-IN-23 是一种铁死亡 (Ferroptosis) 抑制剂。Ferroptosis-IN-23 通过同时激活 Steap4 与谷胱甘肽过氧化物酶 4 (GPX4) 发挥协同作用，进而维持铁代谢稳态。Ferroptosis-IN-23 可逆转神经元铁死亡，抑制细胞中脂质 ROS 积累。Ferroptosis-IN-23 抑制斑马鱼铁死亡，缓解帕金森病斑马鱼模型的神经元凋亡，ROS 积累，多巴胺能神经元损伤。Ferroptosis-IN-23 可用于帕金森病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Ferroptosis-IN-23

Ferroptosis-IN-23 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Ferroptosis-IN-23 相关抗体

Top Publications Citing Use of Products

查看 Glutathione Peroxidase 亚型特异性产品:

查看所有亚型
GPX1 GPX4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ferroptosis-IN-23 is an inhibitor of ferroptosis. Ferroptosis-IN-23 exerts a synergistic effect by simultaneously activating Steap4 and glutathione peroxidase 4 (GPX4), thereby maintaining iron metabolism homeostasis. Ferroptosis-IN-23 reverses neuronal ferroptosis and inhibits lipid ROS accumulation in cells. Ferroptosis-IN-23 inhibits ferroptosis in zebrafish, alleviates neuronal apoptosis, ROS accumulation, and dopaminergic neuron damage in a zebrafish model of Parkinson's disease. Ferroptosis-IN-23 can be used for research on Parkinson's disease[1].

体外研究
(In Vitro)

Ferroptosis-IN-23 (Compound 8h) (10 μM; 48 h) 可强效逆转 RSL3 (HY-100218A)、Erastin (HY-15763)、Ammonium iron(III) citrate (FAC) (HY-B1645) 诱导的 HT-22 海马神经元铁死亡[1]。
Ferroptosis-IN-23 (5-20 μM; 48 h) 以剂量依赖方式抑制 HT-22 海马神经元细胞中由 RSL3 诱导的脂质 ROS 积累[1]。
Ferroptosis-IN-23 (10-20 μM; 48 h) 在 Steap4 沉默的 HT-22 海马神经元细胞中逆转 RSL3 诱导的铁死亡的能力，其中 10 μM 浓度可将细胞活力恢复至 60.4%，表明 Steap4 对其抗铁死亡活性有贡献，但并非必需条件[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ferroptosis-IN-23 相关抗体:

Cell Viability Assay[1]

Cell Line: RSL3-treated HT-22 hippocampal neuronal cells
Concentration: 10 μM (after 4 h pre-treatment with 0.1 μM RSL3)
Incubation Time: 48 h
Result: Reversed RSL3-induced ferroptosis, restoring HT-22 cell viability to 74.3% relative to the control group.

Cell Viability Assay[1]

Cell Line: erastin-treated HT-22 hippocampal neuronal cells
Concentration: 10 μM (after 4 h pre-treatment with 0.3 μM erastin)
Incubation Time: 48 h
Result: Significantly reversed erastin-induced ferroptosis in HT-22 cells, with superior activity relative to a comparator compound.

Cell Viability Assay[1]

Cell Line: FAC-treated HT-22 hippocampal neuronal cells
Concentration: 10 μM (after 4 h pre-treatment with 6 mM FAC)
Incubation Time: 48 h
Result: Reversed FAC-induced ferroptosis in HT-22 cells.

Cell Viability Assay[1]

Cell Line: Steap4-silenced, RSL3-treated HT-22 hippocampal neuronal cells
Concentration: 10-20 μM (after 4 h pre-treatment with 0.1 μM RSL3 in Steap4-silenced cells)
Incubation Time: 48 h
Result: Restored cell viability to 60.4% relative to the control group at 10 μM, while 20 μM showed further improved viability.
体内研究
(In Vivo)

Ferroptosis-IN-23 (2-8 μM; 72 h) 可通过减少 ROS 积累、脂质过氧化并恢复铁稳态及 GPX4 功能，呈剂量依赖性地抑制 RSL3 诱导的野生型 AB 品系斑马鱼铁死亡[1]。
Ferroptosis-IN-23 (2-8 μM; 72 h) 可呈剂量依赖性缓解 6-OHDA (HY-B1081A) 诱导的野生型 AB 品系斑马鱼 (帕金森病模型) 的神经元凋亡与 ROS 积累[1]。
Ferroptosis-IN-23 (2-8 μM; 96 h) 可剂量依赖性地保护 Tg (vmat2: GFP) 品系斑马鱼免受 MPTP (HY-15608) 诱导的多巴胺能神经元损伤，该斑马鱼是帕金森病模型[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: wild-type AB strain (2 hours post-fertilization)[1]
Dosage: 2 μM; 4 μM; 8 μM
Administration: 72 h
Result: Significantly reduced the number of apoptotic brain cells induced by RSL3.
Dose-dependently reduced RSL3-induced reactive oxygen species (ROS) accumulation in zebrafish brains.
Dose-dependently decreased RSL3-induced increases in lipid peroxidation (LPO) and malondialdehyde (MDA) levels.
Dose-dependently reduced RSL3-induced upregulation of hepcidin (HEPC) expression and restored ferroportin (FPN) expression.
Dose-dependently reversed RSL3-induced downregulation of glutathione peroxidase 4 (GPX4a and GPX4b) expression.
Dose-dependently restored RSL3-induced downregulation of Steap4 expression.
Animal Model: wild-type AB strain (2 hours post-fertilization)[1]
Dosage: 2 μM; 4 μM; 8 μM
Administration: immersion; daily replenishment; 72 hours, followed by 24 hours of co-exposure with 6-OHDA
Result: Significantly reduced the number of apoptotic brain cells induced by 6-OHDA.
Dose-dependently reduced 6-OHDA-induced ROS accumulation in zebrafish brains.
Animal Model: Tg(vmat2: GFP) strain (1 day post-fertilization)[1]
Dosage: 2 μM; 4 μM; 8 μM
Administration: immersion; daily replenishment; 96 hours with concurrent MPTP exposure
Result: Dose-dependently reversed MPTP-induced shortening of dopaminergic neuron regions, with recovery toward control levels.
分子量

370.36

Formula

C19H18N2O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ferroptosis-IN-23 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferroptosis-IN-23FerroptosisGlutathione PeroxidaseReactive Oxygen Species (ROS)Ferroptosis inhibitorHT-22 cellsZebrafishParkinson's diseaseferroptosisInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Ferroptosis-IN-23
目录号：
HY-181665
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z