2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Cell Cycle/DNA Damage NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. FGFR Akt PERK Reactive Oxygen Species (ROS) Caspase Pyroptosis PD-1/PD-L1
  4. FGFR-IN-25

FGFR-IN-25 (Compound 19E) 是一种 FGFR 抑制剂 (对 FGFR1 和 FGFR2 的 IC50 值分别为 1.30 nM 和 0.85 nM) 和放射增敏剂。FGFR-IN-25 可有效降低 FGFR1 及其关键下游效应分子 pAKT 和 pERK 的磷酸化水平。FGFR-IN-25 对胃癌、结直肠癌、肝细胞癌、乳腺癌、三阴性乳腺癌和胶质母细胞瘤具有广谱抗肿瘤活性。FGFR-IN-25 与放射疗法联合使用时，可协同激活 ROS-Caspase-3-GSDME 轴，下调 PD-L1 表达，并诱导免疫原性细胞死亡。FGFR-IN-25 与放射疗法联合使用可改善抗肿瘤效果。

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FGFR-IN-25

FGFR-IN-25 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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3.  试用装只面向终端客户。

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FGFR-IN-25 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FGFR-IN-25 (Compound 19E) is a FGFR inhibitor (IC50s: 1.30 nM and 0.85 nM for FGFR1 and FGFR2, respectively) and radiosensitizer. FGFR-IN-25 effectively reduces the phosphorylation of FGFR1 and its key downstream effectors, pAKT and pERK. FGFR-IN-25 exerts broad-spectrum antitumor activity against gastric cancer, colorectal carcinoma, hepatocellular carcinoma, breast cancer, triple-negative breast cancer, and glioblastoma. FGFR-IN-25, when combined with radiotherapy, synergistically activates the ROS-Caspase-3-GSDME axis, downregulates PD-L1 expression, and induces immunogenic cell death (ICD). FGFR-IN-25 combined with radiotherapy improves the antitumor efficacy[1].

IC50 & Target[1]

Caspase 3

 

FGFR1

1.30 nM (IC50)

FGFR2

0.85 nM (IC50)

分子量

669.82

Formula

C36H47N9O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FGFR-IN-25 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR-IN-25FGFRAktPERKReactive Oxygen Species (ROS)CaspasePyroptosisPD-1/PD-L1Fibroblast growth factor receptorPKBProtein kinase BProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinasePD-1/Programmed death-ligand 1gastric cancercolorectal carcinomahepatocellular carcinomabreast cancertriple-negative breast cancerand glioblastomaInhibitorinhibitorinhibit

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