2. Protein Tyrosine Kinase/RTK Apoptosis
  3. FLT3 Apoptosis
  4. Flt-3-IN-1

Flt-3-IN-1 是一种强效的 FLT-3 抑制剂，其 IC50 值为 0.91 μM。Flt-3-IN-1 可导致白血病细胞 G1 期阻滞并诱导细胞凋亡 (apoptosis)。Flt-3-IN-1 可用于癌症研究，如白血病研究。

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Flt-3-IN-1

Flt-3-IN-1 Chemical Structure

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Flt-3-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Flt-3-IN-1 is a potent FLT-3 inhibitor with an IC50 of 0.91 μM. Flt-3-IN-1 can cause leukemia cells G1 phase arrest and induce apoptosis. Flt-3-IN-1 can be used for the research of cancer, such as leukemia[1].

体外研究
(In Vitro)

Flt-3-IN-1 对 HL-60、CCRF-CEM、MOLT-4 白血病细胞均有细胞毒性，IC50 值分别为 0.13 μM、7.5 μM、3.65 μM[1]。
Flt-3-IN-1 (0.13 μM, 24 h) 可将 HL-60 细胞周期阻滞在 G1 期，并诱导细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Flt-3-IN-1 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HL-60 cells
Concentration: 0.13 μM
Incubation Time: 24 h
Result: Increased the proportion of G1 phase cells to 66.59% and decreased the G2/M phase proportion to 4.77%.

Apoptosis Analysis[1]

Cell Line: HL-60 cells
Concentration: 0.13 μM
Incubation Time: 24 h
Result: Showed a total apoptosis rate of 37.7%, including 23.6% early apoptosis and 16.7% late apoptosis.
Upregulated the expression of p53, p27, and p21 proteins in HL-60cells by 4.2-fold, 2.1-fold, and 2.1-fold respectively.
Increased the Bax/Bcl-2 ratio to 0.71 and upregulated caspase-3 expression by 3-fold.
分子量

482.98

Formula

C24H23ClN4O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Flt-3-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flt-3-IN-1FLT3ApoptosisCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3LeukemiacancerFLT-3HL-60CCRF-CEMMOLT-4apoptosisInhibitorinhibitorinhibit

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