2. Metabolic Enzyme/Protease Cytoskeleton Cell Cycle/DNA Damage Apoptosis
  3. Herbicide Microtubule/Tubulin DNA/RNA Synthesis Apoptosis
  4. Fluchloralin

Fluchloralin 是一种二硝基苯胺类除草剂，主要通过抑制微管蛋白 (tubulin) 的合成和细胞分裂，有效控制一年生禾本科和阔叶杂草。Fluchloralin 具有细胞毒性和遗传毒性，可通过激活凋亡 (apoptosis) 信号蛋白、形成 DNA 梯状条带、诱导细胞皱缩和核碎裂来促进细胞凋亡。

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Fluchloralin

Fluchloralin Chemical Structure

CAS No. : 33245-39-5

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Fluchloralin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fluchloralin is a dinitroaniline herbicide that effectively controls annual gramineous and broadleaf weeds primarily by inhibiting tubulin synthesis and cell division. Fluchloralin exhibits cytotoxicity and genotoxicity, and promotes cell apoptosis by activating apoptotic signaling proteins, forming DNA ladder bands, inducing cell shrinkage and nuclear fragmentation[1][2].

体外研究
(In Vitro)

Fluchloralin (5-20 μg/mL; 24-72 h) 在 CHO 和 MEF 细胞中表现出剂量和时间依赖性的细胞毒性[2]。
Fluchloralin (2.5-20.0 μg/mL; 4-12 h) 会在 CHO 细胞中诱导具有统计学意义、时间依赖性的染色体畸变[2]。
Fluchloralin (1.0-20.0 μg/mL; 12 h) 使 CHO 细胞的姐妹染色单体交换水平产生具有统计学意义的升高[2]。
Fluchloralin (5-20 μg/mL; 30 h) 对同步化 MEF 细胞的 DNA 合成产生剂量依赖性抑制作用，且不影响胸苷转运[2]。
Fluchloralin (5-20 μg/mL; 6 h) 可使同步化 MEF 细胞在处理后 12 h 时的 DNA 合成水平下降近 50%，且不影响胸苷转运[2]。
Fluchloralin (5-20 μg/mL; 24-72 h) 可诱导 CHO 细胞发生细胞凋亡，DNA 梯状条带形成及典型的细胞核变化可证明这一点[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fluchloralin 相关抗体:

Cell Cytotoxicity Assay[2]

Cell Line: Chinese hamster ovary (CHO) cells, mouse embryo fibroblast (MEF) cells
Concentration: 5, 10, 15 and 20 μg/mL
Incubation Time: 24 h; 48 h; 72 h
Result: Induced a dose-dependent decrease in cell viability in both cell lines, with greater toxicity observed in CHO cells than MEF cells.
Reduced viability to 50% in CHO cells treated with 20 μg/mL for 72 h.
Reduced viability to 50% in MEF cells treated with 20 μg/mL for 72 h.

Apoptosis Analysis[2]

Cell Line: Chinese hamster ovary (CHO) cells
Concentration: 5, 10 and 20 μg/mL
Incubation Time: 24 h; 48 h; 72 h
Result: Induced a characteristic DNA ladder pattern in agarose gels of DNA from treated CHO cells.
Revealed apoptotic features including cell shrinkage and nuclear fragmentation via microscopic observation.
Induced apoptosis at 20 μg/mL after 72 h of treatment.
体内研究
(In Vivo)

Fluchloralin (0.5-2 mg/L；水体浸泡；共 4 天) 对斑马鱼胚胎具有剂量依赖性发育毒性，包括存活率降低 (LC50 = 2.004 mg/L)、形态缺陷、神经毒性、心脏毒性、肝脏损伤及脑部细胞凋亡增加[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Transgenic zebrafish (olig2:dsRed, cmlc2:dsRed, lfabp:dsRed;elastase:GFP); wild-type zebrafish (reared at 26-28.5 °C on a 13 h light/11 h dark cycle, 8 hours post-fertilization)[1]
Dosage: 0.5 mg/L; 1 mg/L; 2 mg/L
Administration: aquatic immersion; daily; 96 hours
Result: Significantly increased the number of apoptotic cells in the brain region of zebrafish.
Caused developmental toxicity to multiple organs (nervous system, heart, liver, pancreas) in zebrafish embryos.
分子量

355.70

Formula

C12H13ClF3N3O4
CAS 号
中文名称

氯乙氟灵
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Fluchloralin 相关分类

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Keywords:

Fluchloralin33245-39-5氯乙氟灵HerbicideMicrotubule/TubulinDNA/RNA SynthesisApoptosismicrotubule formationneurogenesisCHO cellsMEF cellshuman cancermicrotubule inhibitorzebrafish embryosapoptosisDNA synthesiscell divisionInhibitorinhibitorinhibit

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