2. Others Neuronal Signaling Membrane Transporter/Ion Channel
  3. Isotope-Labeled Compounds Potassium Channel iGluR GABA Receptor
  4. Flupirtine-d6 hydrochloride

Flupirtine-d6 hydrochloride  (Synonyms: D 9998-d6 hydrochloride)

目录号: HY-W709349S
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Flupirtine-d6 (D 9998-d6) hydrochloride 是氘代标记的 Flupirtine hydrochloride (HY-W709349)。Flupirtine hydrochloride 是一种具有口服活性、可穿过血脑屏障的非阿片类镇痛剂和神经保护剂。Flupirtine hydrochloride 是一种神经元钾通道开放剂 (Kv7 激活剂)、NMDA 受体拮抗剂和 GABA 受体激活剂。Flupirtine hydrochloride 可稳定血脑屏障完整性，减轻氧化应激和脑白细胞浸润，促进血管神经发生，抑制钙内流，稳定神经元静息膜电位，并对抗局灶性脑缺血。Flupirtine hydrochloride 具有镇痛、肌肉松弛活性，可保护神经元免受兴奋性毒性、缺血或细胞因子介导的死亡。Flupirtine hydrochloride 作为无解热或抗炎活性的非阿片类镇痛剂发挥作用，对阿片受体无相关亲和力。Flupirtine hydrochloride 可用于局灶性脑缺血、疼痛、阿尔茨海默病或多发性硬化症的研究。

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Flupirtine-d<sub>6</sub> hydrochloride

Flupirtine-d6 hydrochloride Chemical Structure

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Other Forms of Flupirtine-d6 hydrochloride:

Flupirtine-d6 hydrochloride 相关抗体

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  • 生物活性

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生物活性

Flupirtine-d6 (D 9998-d6) hydrochloride is the deuterium labeled Flupirtine hydrochloride (HY-W709349). Flupirtine hydrochloride is an orally active, blood-brain barrier-crossing non-opioid analgesic and neuroprotective agent. Flupirtine hydrochloride is a neuronal potassium channel opener (Kv7 activator), a NMDA receptor antagonist and a GABA receptor activator. Flupirtine hydrochloride stabilizes blood-brain-barrier integrity, reduces oxidative stress and brain leukocyte infiltration, enhances angioneurogenesis, suppresses calcium influx, stabilizes neuronal resting membrane potential, and counteracts focal cerebral ischemia. Flupirtine hydrochloride exhibits analgesic, muscle relaxant properties, protects neurons from excitotoxic, ischemic, or cytokine-mediated death. Flupirtine hydrochloride functions as a non-opioid analgesic without antipyretic or antiphlogistic properties, shows no relevant affinity to opiate receptor. Flupirtine hydrochloride can be used for the research of focal cerebral ischemia, pain, Alzheimer’s disease, or multiple sclerosis[1][2].

产品应用

1. 该化合物可作为示踪剂。
2. 该化合物可作为 NMR、GC-MS 或 LC-MS 分析中的内标品，用于定量分析。
体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Flupirtine-d6 hydrochloride 相关抗体:
分子量

346.82

Formula

C15H12D6ClFN4O2
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Flupirtine-d6 hydrochloride 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flupirtine-d6D 9998-d6Isotope-Labeled CompoundsPotassium ChanneliGluRGABA ReceptorKcsAIonotropic glutamate receptorsGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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