2. FP1-24

FP1-24 是一种非选择性 CK1 激酶抑制剂，对人源 CK1γ1、CK1γ2、CK1γ3 和 CK1δ 的 IC50 分别为 40 nM、10 nM、10 nM，和 40 nM。FP1-24 通过降低 WNT 信号通路激活过程中 LRP5/6 在 T1479 位点的磷酸化水平来发挥活性。FP1-24 对多种激酶的非特异性结合，可能用于特异性 CK1γ 的生物学研究。

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FP1-24

FP1-24 Chemical Structure

CAS No. : 1403557-08-3

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FP1-24 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FP1-24 is a non-selective CK1 kinase inhibitor, with IC50 values of 40 nM, 10 nM, 10 nM, and 40 nM against human CK1γ1, CK1γ2, CK1γ3 and CK1δ, respectively. FP1-24 exerts its activity by reducing the phosphorylation level of LRP5/6 at the T1479 site during WNT signaling pathway activation. The non-specific binding of FP1-24 to multiple kinases can be used for biological studies of specific CK1γ[1].

体外研究
(In Vitro)

FP1-24 (10 μM; 2 h) 可降低 WNT 激活的 HEK293 细胞中 T1479 位点的 LRP6 磷酸化水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FP1-24 相关抗体:
分子量

385.36

Formula

C20H17F2N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FP1-24 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FP1-241403557-08-3WNT signaling pathwayDiscoverX wild-type kinase panelphosphorylationCK1γ1CK1δCK1γ2CK1γ3HEK293 cellsLRP5/6kinase activityInhibitorinhibitorinhibit

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目录号：
HY-181585
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