2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. FR 111142

FR 111142 是一种血管生成抑制剂 (IC50 = 18.4 μM) ，并具有抗炎活性 (IC50 = 20.6 μM)。FR 111142 可抑制毛细血管样管的形成，并可抑制 LPS (HY-D1056) 激活的小鼠巨噬细胞中一氧化氮的产生。FR 111142 可增强低密度脂蛋白 (LDL) 的分解代谢。FR 111142 不会对人内皮祖细胞产生显著细胞毒性，也不会影响小鼠巨噬细胞的细胞活力。FR 111142 可用于癌症、炎症性疾病的研究。

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FR 111142

FR 111142 Chemical Structure

CAS No. : 132340-44-4

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FR 111142 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FR 111142 is an angiogenesis inhibitor (IC50 = 18.4 μM) and has anti-inflammatory activity (IC50 = 20.6 μM). FR 111142 inhibits capillary-like tube formation as well as nitric oxide production in LPS (HY-D1056)-activated murine macrophages. FR 111142 enhances catabolism of low-density lipoprotein (LDL). FR 111142 does not induce significant cytotoxicity in human endothelial progenitor cells, nor affect cell viability of murine macrophages. FR 111142 can be used for the research of cancer, inflammatory diseases[1][2][3].

体外研究
(In Vitro)

FR 111142 (10-20 μM；24 小时) 可抑制人内皮祖细胞的毛细血管管形成，其 IC50 为 18.4 μM，且在 20 μM 浓度下无细胞毒性[1]。
FR 111142 (up to 100 μM) 可完全抑制 RAW264.7 细胞中 LPS 诱导的 NO 生成，其 IC50 为 20.6 μM，且在最高 100 μM 的浓度下不会降低细胞活力[1]。
FR 111142 对 HUVEC 细胞和 EL-4 细胞均有效，IC50 值分别为 5.0 × 10-4 μg/mL 和 3.8 × 10-4 μg/mL[2]。
FR 111142 (10-40 μM；5-25 小时) 可增强 HepG2 细胞中 LDL 的分解代谢[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FR 111142 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: human endothelial progenitor cells
Concentration: 10 μM; 20 μM
Incubation Time: 24 h
Result: Inhibited capillary tube formation with an IC50 of 18.4 μM without causing cytotoxicity at 20 μM.
体内研究
(In Vivo)

FR-111142 (0.3-30 mg/kg/d；静脉注射；1-4 和 7-10 天给药) 对皮内植入 1 x 105 Meth A 细胞接种量的雌性 Balb/c 小鼠的肿瘤具有相当高的活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice (female;
8 weeks old; implanted intradermally at an inoculum size of 1 x 105 Meth A cells per mouse for fibrosarcoma model)
[2]
Dosage: 30 mg/kg/day; 10 mg/kg/day; 3.3 mg/kg/day; 1.0 mg/kg/day; 0.3 mg/kg/day
Administration: i.v.; qd 1-4 and 7-10 d
Result: Significant suppressed tumor growth at 3.3~30mg/kg.
分子量

410.50

Formula

C22H34O7
CAS 号
结构分类
初始来源

Phoma sp. NTOU4195
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FR 111142 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FR 111142132340-44-4FR111142FR-111142VEGFRVascular endothelial growth factor receptorAspergillus fumigatusinflammatory diseasesPhoma sp. NTOU4195Scolecobasidium arenariumcancerlipopolysaccharidenitric oxidehuman endothelial progenitor cellsRAW264.7 cellsmurine macrophagesInhibitorinhibitorinhibit

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