2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage Epigenetics PI3K/Akt/mTOR
  3. Heme Oxygenase (HO) Keap1-Nrf2 Interleukin Related PPAR AMPK Reactive Oxygen Species (ROS)
  4. FSVVPSPK

FSVVPSPK 是一种口服有效的活性肽。FSVVPSPK 主要通过激活 HO-1/Nrf2 通路，在体外和体内发挥显著的抗脂肪生成、抗氧化及抗炎作用。FSVVPSPK 可用于肥胖和代谢紊乱相关方面的研究。

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Custom Peptide Synthesis

FSVVPSPK

FSVVPSPK Chemical Structure

CAS No. : 2016043-82-4

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规格 是否有货
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FSVVPSPK 相关抗体

Top Publications Citing Use of Products

查看 Heme Oxygenase (HO) 亚型特异性产品:

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HO-1 HO-2

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

查看 PPAR 亚型特异性产品:

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PPARα PPARβ/δ PPARγ PPAR PPARδ

查看 AMPK 亚型特异性产品:

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FSVVPSPK is an orally active peptide. FSVVPSPK exerts significant anti-adipogenic, antioxidant and anti-inflammatory effects in vitro and in vivo, mainly through activating the HO-1/Nrf2 pathway. FSVVPSPK can be used in research related to obesity and metabolic disorders[1].

IC50 & Target[1]

IL-6

 

IL-1β

 

HO-1

 

PPARγ

 

体外研究
(In Vitro)

FSVVPSPK (10-100 μM; 48 h) 对 BMMSC 细胞无显著的细胞毒性，但可抑细胞内的活性氧 (ROS) 生成[1]。
FSVVPSPK (10-100 μM；7 days) 通过下调成脂转录因子、抑制生脂酶活性并增强脂肪分解，来抑制 BMMSCs 的成脂分化，在 100 μM 浓度下作用 7 天后，其对脂质积累的最大抑制率为 55.72%[1]。
FSVVPSPK (10-100 μM；2-3 days) 可上调 BMMSCs 细胞质中 HO-1 的表达及细胞核中 Nrf2 的表达[1]。
FSVVPSPK (10-100 μM；7 days) 可抑制 BMMSCs 中促炎细胞因子 (IL-6、IL-1β、TNF-α) 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FSVVPSPK 相关抗体:

Western Blot Analysis[1]

Cell Line: BMMSCs
Concentration: 10, 50 and 100 μM
Incubation Time: 7 d
Result: Suppressed the expression of adipogenic transcription factors (PPARγ, SREBP-1, C/EBPα) and adipocyte protein 2 (aP2).
Inhibited lipogenic enzymes (FAS, LPL).
Upregulated lipolysis-related p-HSL.

Western Blot Analysis[1]

Cell Line: BMMSCs
Concentration: 10, 50 and100 μM
Incubation Time: 3 d (HO-1); 2 d (Nrf2)
Result: Elevated HO-1 expression in the BMMSCs cytoplasm.
Increased Nrf2 expression within the cell nucleus.
体内研究
(In Vivo)

FSVVPSPK (1-10 mg/kg；口服；每日一次；持续 15 周) 可改善高脂饮食肥胖小鼠的肥胖、氧化应激和炎症[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, 6 weeks old, HFD-induced obesity model)[1]
Dosage: 1, 10 mg/kg body weight
Administration: p.o.; daily; 15 weeks
Result: Reduced body weight gain, fat percentage and adipose tissue weight.
Decreased subcutaneous adipose tissue adipocyte size to levels.
Suppressed protein expression of adipogenic transcription factors (PPARγ, SREBP-1, C/EBPα) and lipogenic enzymes (LPL, FAS, aP2), and increased expression of p-HSL and p-AMPK in subcutaneous adipose tissue.
Reduced fasting blood glucose, total cholesterol, LDL, and triglycerides, and increased HDL.
Reduced serum proinflammatory cytokines (IL-6, IL-1β, TNFα), and increased serum antioxidant enzyme activities (CAT, SOD, GPx).
Activated Nrf2 and HO-1 in subcutaneous adipose tissue.
分子量

860.01

Formula

C41H65N9O11
CAS 号
Sequence

Phe-Ser-Val-Val-Pro-Ser-Pro-Lys
Sequence Shortening

FSVVPSPK
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FSVVPSPK 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FSVVPSPK2016043-82-4Heme Oxygenase (HO)Keap1-Nrf2Interleukin RelatedPPARAMPKReactive Oxygen Species (ROS)Heme OxygenaseILPeroxisome proliferator-activated receptorsAMP-activated protein kinaseBMMSCsHFDobese miceInhibitorinhibitorinhibit

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