2. Metabolic Enzyme/Protease
  3. MetAP
  4. Fumarranol

Fumarranol 是 Fumagillin (HY-B0751) 的类似物，是一种选择性 2 型甲硫氨酸氨基肽酶 (MetAP2) 抑制剂，对人源靶点的 IC50 为 3.2 μM。Fumarranol 可抑制牛主动脉内皮细胞的增殖，并在小鼠基质胶栓模型中抑制血管生成。Fumarranol 可用于癌症、糖尿病视网膜病变、年龄相关性黄斑变性的相关研究。

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Fumarranol

Fumarranol Chemical Structure

CAS No. : 912569-37-0

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Fumarranol 相关抗体

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MetAP2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fumarranol, a Fumagillin (HY-B0751) analogue, is a selective type 2 methionine aminopeptidase (MetAP2) inhibitor with a human IC50 of 3.2 μM. Fumarranol inhibits proliferation of bovine aortic endothelial cells and inhibits angiogenesis in a mouse matrigel plug model. Fumarranol can be used for the researches of cancer, diabetic retinopathy, age-related macular degeneration[1].

IC50 & Target[1]

MetAp2

3.2 μM (IC50)

体外研究
(In Vitro)

Fumarranol (0-100 μM) 可选择性抑制重组 hMetAP2 的酶活性，其 IC50 为 3.2 μM，且在 100 μM 浓度下不会抑制 hMetAP1[1]。
Fumarranol 可抑制牛主动脉内皮细胞增殖，其 IC50 为 34 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fumarranol 相关抗体:
体内研究
(In Vivo)

Fumarranol (90 mg/kg) 可抑制体内含有 VEGF 和碱性成纤维细胞生长因子 (basic FGF) 的基质胶小鼠模型中新血管的生成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

280.36

Formula

C16H24O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Fumarranol 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fumarranol912569-37-0MetAPMethionine Aminopeptidasebovine aortic endothelial cellsMetAP1recombinant hMetAP2MetAP2diabetic retinopathyage-related macular degenerationcancertype 2 methionine aminopeptidasemouse matrigel plug modelInhibitorinhibitorinhibit

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目录号：
HY-133806
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