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  4. Furathiocarb

Furathiocarb 是一种氨基甲酸酯类前杀虫剂 (insecticide)，也是一种接触性变应原。Furathiocarb 常用于接触性过敏的相关研究。Furathiocarb 能诱导耳淋巴结细胞中 MHC II 类阳性 B 细胞显著增殖，并诱导产生 Th1 细胞因子 (如 IL-2、TNF-γ 和 IFN-γ)。但 Furathiocarb 不引起小鼠的呼吸道过敏。Furathiocarb 经离体大鼠腹部皮肤吸收后，会完全代谢为克百威，其渗透量随时间和剂量增加而上升。Furathiocarb 的乳油 (EC) 制剂和可湿性粉剂 (WP) 制剂的皮肤渗透率均高于 Furathiocarb，且两种制剂之间无显著差异。

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Furathiocarb

Furathiocarb Chemical Structure

CAS No. : 65907-30-4

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5 mg ￥520
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10 mg ￥784
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25 mg ￥1344
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50 mg ￥2016
In-stock
100 mg ￥3040
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Furathiocarb 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Furathiocarb is a carbamate pro-insecticide and a contact allergen. Furathiocarb is commonly used in studies related to contact allergy. Furathiocarb induces significant proliferation of MHC II-positive B cells in auricular lymph node cells and induces the production of Th1 cytokines (such as IL-2, TNF-γ and IFN-γ). However, Furathiocarb does not induce respiratory allergy in mice. After absorption through the abdominal skin of isolated rats, Furathiocarb is completely metabolized into carbofuran, and its permeation amount increases with time and dosage. The skin permeation rates of both emulsifiable concentrate (EC) and wettable powder (WP) formulations of Furathiocarb are higher than that of Furathiocarb itself, with no significant difference between the two formulations[1][2].

体内研究
(In Vivo)

Furathiocarb (0.1-3%；局部给药；每日 1 次；连续 3 天) 可在雌性 CBA/Jn 小鼠中发挥皮肤致敏剂作用，在 3%剂量下可观察到局部淋巴结试验阳性反应，其 EC3 值为 1.08%[1]。
Furathiocarb (1%(致敏)、0.01-0.1%(激发)；致敏采用局部给药，激发采用气管内给药；致敏于第 1-3、8-10、15-17 天进行，激发于第 31 天单次给药) 在雌性 BALB/c 小鼠经长期皮肤致敏及气管内激发后，肺相关淋巴结无显著 Th2 激活，未诱导出呼吸道变应原免疫特征[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice with Allergic contact dermatitis (female, 7 weeks old)[1]
Dosage: 1% (sensitization); 0.01% (challenge), 0.1% (challenge)
Administration: topical; on days 1-3, 8-10, 15-17 (sensitization); topical; single dose on day 31 (challenge)
Result: Did not cause statistically significant increases in total serum IgE levels in any furathiocarb-treated groups relative to controls.
Caused statistically significant increases in total lymphocyte counts, MHC Class II-positive B-cell counts, and IgE-positive B-cell counts in auricular lymph nodes at 0.1% challenge dose (after 1% sensitization) relative to control groups.
Caused IgE-positive B-cell counts to be significantly higher than in the low-dose challenge group at 0.1% challenge dose (after 1% sensitization).
Caused statistically significant increases in total lymphocyte counts and MHC Class II-positive B-cell counts in auricular lymph nodes at 0.01% challenge dose (after 1% sensitization) relative to non-sensitized controls.
Induced statistically significant increases in Th1 cytokines (IL-2, TNF-α, IFN-γ) and Th2 cytokines (IL-4, IL-5, IL-10, IL-13) in ex situ culture of auricular lymph node cells relative to controls, though Th2 cytokine responses were milder than those induced by 2,4-D.
Animal Model: BALB/c mice with Respiratory allergy (female, 7 weeks old)[1]
Dosage: 1% (sensitization); 0.01% (challenge), 0.1% (challenge)
Administration: topical; on days 1-3, 8-10, 15-17 (sensitization); intratracheal; single dose on day 31 (challenge)
Result: Did not cause statistically significant increases in total IgE levels in serum or BALF in any furathiocarb-treated groups relative to controls.
Did not cause elevations in total or differential cell counts (eosinophils, neutrophils, macrophages) in BALF, aside from a mild, statistically significant increase in MIP-1β levels in the high-dose challenge group relative to controls.
Did not cause statistically significant increases in IgE-positive B-cell or MHC Class II-positive B-cell counts in lung-associated lymph nodes.
Did not induce statistically significant increases in Th2 cytokines (IL-4, IL-10, IL-13) in ex situ culture of lung-associated lymph node cells relative to controls.
分子量

382.48

Formula

C18H26N2O5S
CAS 号
中文名称

呋线威
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Furathiocarb 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Furathiocarb65907-30-4呋线威InsecticideIL-2MHC Class II-positive B-cellsCBA/Jn miceTh1 cytokinescontact allergyauricular lymph node cellsrat abdominal skinIFN-γTNF-γBALB/c miceInhibitorinhibitorinhibit

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