2. Metabolic Enzyme/Protease
  3. FXR
  4. FXR agonist 16

FXR agonist 16 是一种 FXR 激动剂，其 EC50 为 2.2 μM。FXR agonist 16 可激活 FXR 的转录活性，上调 SHP 和 BSEP 的表达，并下调 Cyp7a1 的表达。FXR agonist 16 具有保肝活性，可降低游离脂肪酸诱导的肝细胞损伤模型中的 AST 和 ALT 水平。FXR agonist 16 可用于肝损伤的研究。

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FXR agonist 16

FXR agonist 16 Chemical Structure

CAS No. : 3099198-78-1

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FXR agonist 16 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FXR agonist 16 is a FXR agonist with an EC50 of 2.2 μM. FXR agonist 16 activates FXR transcriptional activity, upregulates SHP and BSEP, and downregulates Cyp7a1. FXR agonist 16 exhibits hepatoprotective activity and reduces AST and ALT levels in free fatty acid-induced hepatocellular injury models. FXR agonist 16 can be used for the research of liver injury[1].

体外研究
(In Vitro)

FXR agonist 16 (Compound 3q) (10-100 μM; 24 h) 在稳定转染的 HEK293 细胞中作为 FXR 激动剂发挥作用，其 EC50 为 2.2 μM[1]。
FXR agonist 16 (1-20 μM; 24 h) 在游离脂肪酸 (FFA) 损伤的 AML12 细胞中表现出保肝活性，可降低肝损伤标志物，且在最高 25 μM 的浓度下无明显细胞毒性[1]。
FXR agonist 16 (1-10 μM) 可调控 AML12 细胞中 FXR 下游靶基因的表达上调 SHP 和 BSEP，同时下调 Cyp7a1[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FXR agonist 16 相关抗体:

ELISA Assay[1]

Cell Line: FFA-injured AML12 cells
Concentration: 1, 10, 20 μM
Incubation Time: 24 h
Result: Lowered both AST and ALT levels.
分子量

372.56

Formula

C23H32O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FXR agonist 16 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

FXR agonist 163099198-78-1FXR agonist16FXR agonist-16FXRNR1H4Cyp7a1FXR ligand-binding domainBSEPmetabolic dysfunction associated fatty liver diseaseAML12 cellsHEK293 cellshepatocellular injury modelsSHPInhibitorinhibitorinhibit

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