2. Cell Cycle/DNA Damage
  3. G-quadruplex
  4. G-quadruplex ligand 5

G-quadruplex ligand 5 是一种 G-四链体 (G4) 配体。G-quadruplex ligand 5 可选择性稳定癌症相关 G4 寡核苷酸，并对癌细胞表现出细胞毒性。G-quadruplex ligand 5 可用于癌症研究。

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G-quadruplex ligand 5

G-quadruplex ligand 5 Chemical Structure

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G-quadruplex ligand 5 相关抗体

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  • 生物活性

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生物活性

G-quadruplex ligand 5 is a G-quadruplex (G4) ligand. G-quadruplex ligand 5 selectively stabilizes cancer-associated G4 oligonucleotides and shows cytotoxicity toward cancer cells. G-quadruplex ligand 5 can be used for the research of cancer[1].

体外研究
(In Vitro)

G-quadruplex ligand 5 (Compound 2o) (10 μM) 可选择性地将癌症相关 G4 寡核苷酸的稳定性提高最多 5 °C，且不会稳定双链 DNA[1]。
G-quadruplex ligand 5 (10 μM) 可与 c-Myc G4 序列结合，结合常数 Ka 为 1.7 ± 0.1 μM-1[1]。
G-quadruplex ligand 5 可结合反平行 telo22、平行 c-Myc 以及杂合 telo23 G4 的沟区和环区，引发广泛的光谱扰动[1]。
G-quadruplex ligand 5 (1-100 μM; 72 h) 在黑暗中孵育 72 h 后，对 HeLa 癌细胞表现出选择性细胞毒性，IC50 为 7.8 ± 0.4 μM，而在健康 HDF 细胞中无明显毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

G-quadruplex ligand 5 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HeLa cervical cancer cells, healthy human dermal fibroblasts (HDF)
Concentration: 1-100 μM
Incubation Time: 72 h (dark incubation)
Result: Exhibited an IC50 of 7.8 ± 0.4 μM in HeLa cells.
Showed negligible cytotoxicity in HDF cells (IC50 > 100 μM).
分子量

784.51

Formula

C29H30I2N4O2S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

G-quadruplex ligand 5 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G-quadruplex ligand 5G-quadruplexc-Myc G4 sequencecancerduplex DNAhybrid telo23 G4sparallel c-Mycantiparallel telo22HeLa cancer cellsG4 oligonucleotidesHDF cellsInhibitorinhibitorinhibit

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