2. Anti-infection
  3. Parasite
  4. G6PD-IN-2

G6PD-IN-2 是一种恶性疟原虫葡萄糖-6-磷酸脱氢酶 (G6PD) 抑制剂，其 IC50 值为 0.2 μM。G6PD-IN-2 对恶性疟原虫葡萄糖-6-磷酸脱氢酶-6-磷酸葡萄糖酸内酯酶 (PfGluPho) 仅表现出微弱的抑制活性，IC50 值为 22.0 μM。G6PD-IN-2 可抑制恶性疟原虫 3D7 株的生长，且在肝细胞中细胞毒性较低。G6PD-IN-2 可用于疟疾的相关研究。

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G6PD-IN-2

G6PD-IN-2 Chemical Structure

CAS No. : 333311-00-5

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G6PD-IN-2 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

G6PD-IN-2 is a Plasmodium falciparum glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 value of 0.2 μM. G6PD-IN-2 exerts weak inhibitory activity on Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (PfGluPho) with an IC50 value of 22.0 μM. G6PD-IN-2 inhibits growth of Plasmodium falciparum 3D7 strain and exhibits low cytotoxicity in hepatocytes. G6PD-IN-2 can be used for the research of malaria[1].

体外研究
(In Vitro)

G6PD-IN-2 (Compound CB83) 对重组人 G6PD 表现出时间依赖性抑制作用，在预孵育 1 小时/后孵育 1 小时的条件下其 IC50 为 0.2 μM，但对重组恶性疟原虫 PfGluPho 仅表现出微弱的、非时间依赖性抑制作用，相同预孵育/后孵育条件下其 IC50 为 22.0 μM[1]。
G6PD-IN-2 (共 72 h) 可以 5.3 μM 的 IC50 体外抑制 Plasmodium falciparum 3D7 株寄生虫的生长[1]。
G6PD-IN-2 (0.01-50 μM; 24 h) 对 Fa2N-4 人永生化肝细胞表现出低细胞毒性，其 LC50 为 81.3 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

G6PD-IN-2 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Fa2N-4 human immortalized hepatocytes
Concentration: 0.01-50 μM
Incubation Time: 24 h
Result: Showed a cytotoxicity LC50 of 81.3 μM.
分子量

327.40

Formula

C18H17NO3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

G6PD-IN-2 相关分类

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Keywords:

G6PD-IN-2333311-00-5ParasiteFa2N-4 hepatocytesmalariaimmortalized human Fa2N-4 hepatocytesPlasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonasePlasmodium falciparum 3D7 strainrecombinant human G6PDPlasmodium falciparum PfGluPhoPlasmodium falciparum 3D7 parasiteshuman glucose-6-phosphate dehydrogenaseInhibitorinhibitorinhibit

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