2. Anti-infection Membrane Transporter/Ion Channel NF-κB Immunology/Inflammation
  3. Bacterial Na+/K+ ATPase NF-κB Nuclear Factor of activated T Cells (NFAT)
  4. (-)-γ-Cuparenol

(-)-γ-Cuparenol 是一种倍半萜类化合物，对猪源 Na+/K+-ATPase 的 IC50 为 23.6 μg/mL。(-)-γ-Cuparenol 可降低 Jurkat 细胞中植物血凝素 (PHA) 诱导的 NF-AT 和 NF-κB 激活。(-)-γ-Cuparenol 可抑制革兰氏阳性菌和部分革兰氏阴性菌的生长。(-)-γ-Cuparenol 对 Candida albicans 表现出弱抑制活性。(-)-γ-Cuparenol 可用于免疫调节、心血管疾病和细菌感染相关研究。

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(-)-γ-Cuparenol

(-)-γ-Cuparenol Chemical Structure

CAS No. : 1357469-94-3

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(-)-γ-Cuparenol 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(-)-γ-Cuparenol is a sesquiterpene compound with an IC50 of 23.6 μg/mL against porcine Na+/K+-ATPase. (-)-γ-Cuparenol reduces phytohemagglutinin (PHA)-induced activation of NF-AT and NF-κB in Jurkat cells. (-)-γ-Cuparenol inhibits the growth of Gram-positive bacteria and some Gram-negative bacteria. (-)-γ-Cuparenol exhibits weak inhibitory activity against Candida albicans. (-)-γ-Cuparenol is applicable for research related to immunoregulation, cardiovascular diseases and bacterial infections[1][2].

体外研究
(In Vitro)

(-)-γ-Cuparenol (10 μg/mL; 4 h) 可显著降低 PHA 诱导的 Jurkat T 淋巴细胞中 NF-AT 和 NF-κB 的活化水平[1]。
(-)-γ-Cuparenol (0.05-100 μg/mL; 24 h) 可抑制金黄色葡萄球菌、枯草芽孢杆菌、藤黄微球菌、普通变形杆菌和鼠伤寒沙门氏菌的生长，其 MIC 为 50 μg/mL，但在浓度高达 100 μg/mL 时对大肠杆菌的生长无抑制作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(-)-γ-Cuparenol 相关抗体:
分子量

218.33

Formula

C15H22O
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(-)-γ-Cuparenol 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-γ-Cuparenol1357469-94-3BacterialNa+/K+ ATPaseNF-κBNuclear Factor of activated T Cells (NFAT)Sodium potassium pumpNuclear factor-κBNuclear factor-kappaBGram-positive bacteriaJurkat T lymphocytesJurkat cellsGram-negative bacteriaNa+/K+-ATPaseporcine cerebral cortexNF-ATEscherichia coliCandida albicansInhibitorinhibitorinhibit

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