2. Anti-infection
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  4. γ-Cyhalothrin

γ-Cyhalothrin 是一种具有口服活性且可穿透血脑屏障的 II 型合成拟除虫菊酯类杀虫剂。γ-Cyhalothrin 是 λ-Cyhalothrin (HY-B0836) 的杀虫活性对映体。γ-Cyhalothrin 可破坏电压门控钠通道，诱导大鼠流涎并出现自发活动减少。γ-Cyhalothrin 会对水生无脊椎动物和鱼类产生毒性作用，引发水生群落水平的效应，并可抑制住宅草坪交错带中寻求宿主的肩突硬蜱 (Ixodes scapularis) 若虫。γ-Cyhalothrin 可用于杀虫的相关研究。

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γ-Cyhalothrin

γ-Cyhalothrin Chemical Structure

CAS No. : 76703-62-3

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Other Forms of γ-Cyhalothrin:

γ-Cyhalothrin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

γ-Cyhalothrin is an orally active, blood-brain barrier permeable Type II synthetic pyrethroid insecticide. γ-Cyhalothrin is the insecticidally active enantiomer of λ-Cyhalothrin (HY-B0836). γ-Cyhalothrin disrupts voltage-gated sodium channels, induces salivation and reduces spontaneous activity in rats. γ-Cyhalothrin exerts toxic effects on aquatic invertebrates and fish, triggers community-level effects in aquatic ecosystems, and inhibits host-seeking Ixodes scapularis nymphs in residential lawn ecotones. γ-Cyhalothrin is applicable to insecticidal-related research[1][2][3].

体外研究
(In Vitro)

Gamma-cyhalothrin 对无脊椎动物表现出 HC5 为 0.47 ng/L 的中值，对鱼类的 HC5 中值为 23.7 ng/L，群落水平的无观察效应浓度 (NOEC群落) 为 5 ng/L[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

γ-Cyhalothrin 相关抗体:
体内研究
(In Vivo)

γ-Cyhalothrin (0.05% 制剂，362 g/92.9 m2；单次) 在处理后长达 4 周内，可使住宅草坪交错带样地中寻求宿主的肩突硬蜱 (Ixodes scapularis) 若虫数量减少 89-97.6%[2]。

γ-Cyhalothrin (0.0938-4 mg/kg；口服；单次) 可使雄性 Long-Evans 大鼠的自发活动呈剂量依赖性降低，诱导流涎[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: nymphal stage[2]
Dosage: 0.05% γ-Cyhalothrin, 362 g/92.9 m2 (equivalent to 292.5 mg active ingredient per 150 m2 plot)
Administration: topical application; single dose
Result: Reduced nymphal Ixodes scapularis density by 97.7% in Eau Claire County and 97.4% in Sauk County at 1 week postapplication.
Reduced density by 91.5% in Eau Claire County at 3 weeks and 89.5% at 4 weeks postapplication.
Reduced density by 90.9% in Sauk County at 2 weeks and 97.6% at 3 weeks postapplication.
Limited treated homes with at least one nymphal tick posttreatment to a range of 4.2% (Eau Claire County, week 1) to 29.2% (Eau Claire County, week 3), compared to 50-81.5% of placebo homes.
Lowered the odds of detecting a nymphal tick in treated plots to 0.04 times that of placebo plots at week 1 and 0.09 times that of placebo plots at week 3, after adjusting for plot characteristics and study area.
Animal Model: Long-Evans (male, 63-67 days old, 331.1-361.7 g)[3]
Dosage: 0.0938 mg/kg, 0.188 mg/kg, 0.375 mg/kg, 0.75 mg/kg, 1.5 mg/kg, 3 mg/kg; additional pilot doses: 0.3 mg/kg, 1 mg/kg, 2 mg/kg, 4 mg/kg
Administration: p.o.; single dose
Result: Produced statistically significant decreases in locomotor activity counts relative to controls at doses ≥0.75 mg/kg.
Achieved an ED50 of 1.29 mg/kg for reducing locomotor activity.
Reached a benchmark dose (BMD) of 0.256 mg/kg for a 1 standard deviation decrease in activity.
Induced salivation at 13% incidence with 0.75 mg/kg, 17% incidence with 1 mg/kg, 69% incidence with 1.5 mg/kg, 92% incidence with 2 mg/kg, and 100% incidence with 3 mg/kg and 4 mg/kg.
Associated a 50% decrease in locomotor activity with a plasma concentration of 486.1 ng/mL and a brain concentration of 13.37 ng/g.
Showed a strong positive linear correlation between brain and plasma concentrations, with both tissue levels correlating significantly with decreases in locomotor activity counts.
分子量

449.85

Formula

C23H19ClF3NO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

γ-Cyhalothrin 相关分类

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Keywords:

γ-Cyhalothrin76703-62-3ParasiteinsecticideIxodes scapularisLong-EvansratInhibitorinhibitorinhibit

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