2. Others Apoptosis Cell Cycle/DNA Damage
  3. Drug Derivative Apoptosis DNA/RNA Synthesis
  4. Gem-C12

Gem-C12 是一种 Gemcitabine (HY-17026) 前药。Gem-C12 可终止 DNA 链延伸、抑制核酸合成并诱导凋亡 (Apoptosis)。Gem-C12 能够抑制胶质瘤细胞增殖。Gem-C12 和 Honokiol (HY-N0003) 表现出协同抗胶质母细胞瘤活性。Gem-C12 可用于多形性胶质母细胞瘤的相关研究。

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Gem-C12

Gem-C12 Chemical Structure

CAS No. : 849139-19-1

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Gem-C12 相关抗体

Top Publications Citing Use of Products

查看 DNA/RNA Synthesis 亚型特异性产品:

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RNASE L DNA Polymerases

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Gem-C12 is a prodrug of Gemcitabine (HY-17026). Gem-C12 terminates DNA chain elongation, inhibits nucleic acid synthesis and induces Apoptosis. Gem-C12 inhibits the proliferation of glioma cells. Gem-C12 and Honokiol (HY-N0003) exhibit synergistic anti-glioblastoma activity. Gem-C12 can be used in research related to glioblastoma multiforme[1].

体外研究
(In Vitro)

Gem-C12 (24 h) 可抑制胶质母细胞瘤 U87 细胞的活力，孵育 24 h 后的 IC50 为 15.74 μM[1]。
摩尔比为 1:1 的游离 Gem-C12 与 HNK (24 h) 联合可抑制胶质母细胞瘤 U87 细胞的活性，孵育 24 h 后其 Gem-C12 的 IC50 为 8.75 μM，协同作用 CI 为 0.78[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gem-C12 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route Cmax AUC0-∞ T1/2
Rat[1] 8.5 μmol/Kg i.v. 1250 ± 187 ng/mL 801 ng·h/mL 1.14 h
体内研究
(In Vivo)

包载 Gem-C12 和 HNK (摩尔比 1:1) 的透明质酸接枝胶束 (25 μmol/kg；静脉注射；每 3 天 1 次；共 6 次给药) 在雄性 Balb/c 裸鼠中实现了 84.8% 的肿瘤抑制率，并能有效抑制皮下胶质母细胞瘤的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

445.50

Formula

C21H33F2N3O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Gem-C12 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gem-C12849139-19-1Drug DerivativeApoptosisDNA/RNA SynthesisDrug derivativehonokiolnucleic acidblood-brain barrierBalb/c nude miceglioma cellsapoptosisglioblastoma multiformeglioblastomaDNA chain elongationhuman glioblastoma U87 cellsInhibitorinhibitorinhibit

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