1. Gene
  2. ARPC5 - actin related protein 2/3 complex subunit 5 Gene

ARPC5 - actin related protein 2/3 complex subunit 5 Gene

中文名称:肌动蛋白相关蛋白 2/3 复合亚基 5

种属: Homo sapiens

同用名: ARC16; p16-Arc; dJ127C7.3

基因 ID: 10092 | 基因类型: protein coding

关于 ARPC5

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:183,620,846-183,635,783 (from NCBI)

This gene has 5 transcripts (splice variants), 296 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 104.2), appendix (RPKM 91.8) and 25 other tissues.

功能概要

该基因编码人类 Arp2/3 蛋白复合物的七个亚基之一。 Arp2/3 蛋白复合物与细胞中肌动蛋白聚合的控制有关,并在进化过程中得以保存。该基因编码的蛋白质 p16 亚基的确切作用尚未确定。已经观察到该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供,2012 年 7 月]

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

ARPC5 基因产物(2)

mRNA Protein Name
NM_001270439.2 NP_001257368.1 actin-related protein 2月3日 complex subunit 5 isoform 2
NM_005717.4 NP_005708.1 actin-related protein 2月3日 complex subunit 5 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to actin filament binding IDA
IDA: 通过直接分析推断
11741539 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11162547 GOA
enables structural constituent of cytoskeleton IDA
IDA: 通过直接分析推断
11741539 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Arp2/3 complex-mediated actin nucleation IDA
IDA: 通过直接分析推断
11741539 GOA
involved in cell migration IMP
IMP: 通过突变表型推断
22378351 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Arp2/3 protein complex IDA
IDA: 通过直接分析推断
11741539 GOA
located in nucleus IMP
IMP: 通过突变表型推断
37349293 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ARPC5 蛋白结构

P16-Arc

P16-Arc: ARP2/3 complex 16 kDa subunit (p16-Arc) (10 - 151)

  • 0
  • 100
  • 151 a.a.
蛋白主名 其他名称

actin-related protein 2/3 complex subunit 5

Arp2/3 protein complex subunit p16

ARPC5 抗体

目录号 产品名 应用 反应物种
HY-P82109 p16 ARC Antibody (YA1854) WB, IHC-P, IP Human, Mouse, Rat
HY-P82109A p16 ARC Antibody (YA1854)(PBS only) WB, IHC-P, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Mandibular Cancer

Mandibular Neoplasms

Malignant Neoplasm Of Inferior Maxilla

Malignant Neoplasm Of Lower Jaw Bone

Malignant Neoplasm Of Mandible

Mandible Cancer

Mandibular Neoplasm

Neoplasm Of Mandible

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ARPC5 VGNC VGNC:53328
Mus musculus ARPC5 MGD MGI:1915021
Rattus norvegicus ARPC5 RGD RGD:1311791
Bos taurus ARPC5 VGNC VGNC:26165