IFNL4 - interferon lambda 4 (gene/pseudogene) Gene

中文名称：干扰素 λ 4 (基因/假基因)

种属: Homo sapiens

同用名: IFNAN

关于 IFNL4

功能概要

该基因是一种多态性假基因，在某些人类中，它编码干扰素 (IFN) λ 4 蛋白。人类具有二核苷酸 TT/deltaG 等位基因的多态性。与非人类灵长类动物的祖先状态相比，TT 等位基因在该基因的编码区产生移码，预计会诱导无义介导的 mRNA 衰变。这个等位基因，以及这个基因第一个内含子中的一个等位基因，已经经历了频率的快速增加并显示出正选择的迹象。这些等位基因的原始状态与清除丙型肝炎病毒的能力受损有关。该基因与其他 III 型干扰素 (IFN) 一样，与 IFN λ 受体复合物 (IFNLR) 相互作用，后者的信号传导通常仅限于上皮细胞。该基因位于染色体 19q13.2 上的四个 III 型 IFN 基因簇和至少两个假基因中。通常，干扰素是响应病毒感染而产生的，并通过激活 JAK-STAT 通路和上调抗病毒基因来阻止病毒复制和传播到未感染的细胞。已经描述了该基因的多个可变剪接转录物，但它们的生物学有效性和蛋白质编码状态仍在确定中。[RefSeq 提供，2017 年 5 月]

This gene is a polymorphic pseudogene which, in some humans, encodes the interferon (IFN) lambda 4 protein. Humans are polymorphic for the dinucleotide TT/deltaG allele. Compared to the ancestral state in non-human primates, the TT allele produces a frameshift in the coding region of this gene which is predicted to induce nonsense-mediated mRNA decay. This allele, and an allele in the first intron of this gene, have experienced a rapid increase in frequency and show indications of positive selection. The ancestral states of these alleles are associated with an impaired ability to clear hepatitis C virus. This gene, like Other type III interferons (IFNs), interacts with the IFN lambda receptor complex (IFNLR) whose signaling is generally restricted to epithelial cells. This gene resides in a cluster of four type III IFN genes and at least two pseudogenes on chromosome 19q13.2. In general, interferons are produced in response to viral Infection and block viral replication and propagation to uninfected cells by activating the JAK-STAT pathway and up-regulating Antiviral genes. Multiple alternatively spliced transcripts have been described for this gene but their biological validity and protein coding status is still being ascertained. [provided by RefSeq, May 2017]