IPO7 - importin 7 Gene

中文名称：导入 7

种属: Homo sapiens

同用名: Imp7; RANBP7

关于 IPO7

功能概要

importin-alpha/beta 复合物和 GTPase Ran 介导具有经典核定位信号的蛋白质的核输入。由该基因编码的蛋白质是大约 20 个潜在 Ran 目标的成员，这些目标共享与 importin-beta 的 Ran 结合位点相关的序列基序。与 importin-beta 类似，该蛋白可阻止 RanGAP1 激活 Ran 的 GTP 酶并抑制 RanGTP 上的核苷酸交换，并且还直接结合核孔复合物，在那里它与 importin-beta 和转运蛋白竞争结合位点。这种蛋白质具有 Ran 依赖性运输循环，它可以快速双向穿过核膜。至少有四种 importin beta 样转运受体，即 importin beta 本身、transportin、RanBP5 和 RanBP7，直接结合并输入核糖体蛋白。[RefSeq 提供，2008 年 7 月]

The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. [provided by RefSeq, Jul 2008]