2. Gene
  3. ERN2 - endoplasmic reticulum to nucleus signaling 2 Gene

ERN2 - endoplasmic reticulum to nucleus signaling 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：内质网到细胞核信号 2

种属: Homo sapiens

同用名: IRE1b; IRE2p; hIRE2p; IRE1-BETA

基因 ID: 10595 | 基因类型: protein coding

关于 ERN2

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:23,690,310-23,713,222 (from NCBI)

This gene has 7 transcripts (splice variants), 312 orthologues and 1 paralogue. Biased expression in stomach (RPKM 26.7), colon (RPKM 17.0) and 5 other tissues.

功能概要

启用多项功能，包括 ATP 绑定活动；镁离子结合活性；和蛋白丝氨酸/苏氨酸激酶活性。参与多个过程，包括细胞凋亡染色体浓缩；转录的负调控，DNA 模板化；和 rRNA 分解代谢过程。预计位于内质网膜和内质网质控室。预计是膜的组成部分。预计是 IRE1-TRAF2-ASK1 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including apoptotic chromosome condensation; negative regulation of transcription, DNA-templated; and rRNA catabolic process. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum quality control compartment. Predicted to be integral component of membrane. Predicted to be part of IRE1-TRAF2-ASK1 complex. [provided by Alliance of Genome Resources, Apr 2022]

ERN2 基因产物(2)

mRNA Protein Name
NM_001308220.2 NP_001295149.2 serine/threonine-protein kinase/endoribonuclease IRE2 isoform b precursor
NM_033266.4 NP_150296.4 serine/threonine-protein kinase/endoribonuclease IRE2 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
11175748 GOA
enables endonuclease activity IDA
IDA: 通过直接分析推断
11175748 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
11175748 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
11175748 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in apoptotic chromosome condensation IMP
IMP: 通过突变表型推断
11175748 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
11175748 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
11175748 GOA
involved in rRNA catabolic process IDA
IDA: 通过直接分析推断
11175748 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ERN2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (571 - 829)

Ribonuc_2-5A

Ribonuc_2-5A: Ribonuclease 2-5A (834 - 959)

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  • 974 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase/endoribonuclease IRE2

ER to nucleus signalling 2

关联疾病

疾病名称 别名
Ileocolitis

Iieocolitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04510 ERN2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ERN2 VGNC VGNC:72283
Rattus norvegicus ERN2 RGD RGD:1308743
Felis catus ERN2 VGNC VGNC:61953
Canis familiaris ERN2 VGNC VGNC:40465
Mus musculus ERN2 MGD MGI:1349436
Bos taurus ERN2 VGNC VGNC:28593
Others ERN2 NCBI
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