2. Gene
  3. Card11 - caspase recruitment domain family, member 11 Gene

Card11 - caspase recruitment domain family, member 11 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: BIMP3; CARMA1; 0610008L17Rik; 2410011D02Rik

基因 ID: 108723 | 基因类型: protein coding

关于 Card11

功能概要

Predicted to enable CARD domain binding activity and protein self-association. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and positive regulation of T cell receptor signaling pathway. Acts upstream of or within several processes, including lymphocyte differentiation; positive regulation of interleukin-2 production; and regulation of lymphocyte activation. Located in immunological synapse. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma; immunodeficiency 11A; and immunodeficiency 11B. Orthologous to human CARD11 (Caspase recruitment domain family member 11). [provided by Alliance of Genome Resources, Apr 2022]

Card11 基因产物(1)

mRNA Protein Name
NM_175362.2 NP_780571.2 caspase recruitment domain-containing protein 11
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12356734 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within B cell differentiation IMP
IMP: 通过突变表型推断
12818158 MGI
acts upstream of B cell proliferation IMP
IMP: 通过突变表型推断
12867038 MGI
acts upstream of or within B cell proliferation IMP
IMP: 通过突变表型推断
12818158 MGI
acts upstream of CD4-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
12867038 MGI
acts upstream of T cell activation IMP
IMP: 通过突变表型推断
12867038 MGI
acts upstream of or within T cell activation IMP
IMP: 通过突变表型推断
12818158 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: 通过突变表型推断
12818158 MGI
acts upstream of or within immunoglobulin production IMP
IMP: 通过突变表型推断
12818158 MGI
acts upstream of interleukin-2 production IMP
IMP: 通过突变表型推断
12867038 MGI
acts upstream of or within interleukin-2 production IMP
IMP: 通过突变表型推断
12818158 MGI
acts upstream of or within lymphocyte activation IMP
IMP: 通过突变表型推断
12818158 MGI
acts upstream of or within positive regulation of B cell proliferation IMP
IMP: 通过突变表型推断
12867038 MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
12867038 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
12154356 MGI
acts upstream of or within positive regulation of T cell activation IMP
IMP: 通过突变表型推断
12867038 MGI
involved in positive regulation of T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
12154356 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
12154356 MGI
acts upstream of or within positive regulation of interleukin-2 production IMP
IMP: 通过突变表型推断
12867038 MGI
acts upstream of or within regulation of B cell differentiation IMP
IMP: 通过突变表型推断
12867038 MGI
acts upstream of or within regulation of T cell differentiation IMP
IMP: 通过突变表型推断
12867038 MGI
acts upstream of or within regulation of immune response IMP
IMP: 通过突变表型推断
12867038 MGI
acts upstream of or within signal transduction IDA
IDA: 通过直接分析推断
12356734 MGI
acts upstream of or within thymic T cell selection IMP
IMP: 通过突变表型推断
12867038 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in immunological synapse IDA
IDA: 通过直接分析推断
23793062 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
12867038 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

caspase recruitment domain-containing protein 11

CARD-containing MAGUK protein 1

carma 1

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-142648 MLT-985 Inhibitor 99.49% 否
HY-174371 INNO-220 98.60% 否
HY-142648A (R)-MLT-985 Inhibitor / 否
HY-182706 NSC 373981 Inhibitor / 否
HY-RS01916 CARD11 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17847 Card11 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24315 Card11 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Card11 NCBI NCBI:84433
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