1. Gene
  2. CAPN11 - calpain 11 Gene

CAPN11 - calpain 11 Gene

中文名称:钙蛋白酶 11

种属: Homo sapiens

同用名: calpain11

基因 ID: 11131 | 基因类型: protein coding

关于 CAPN11

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,158,820-44,184,401 (from NCBI)

This gene has 5 transcripts (splice variants), 271 orthologues and 20 paralogues. Restricted expression toward testis (RPKM 18.7).

功能概要

钙蛋白酶构成细胞内钙依赖性半胱氨酸蛋白酶家族。这个超家族有八个成员。它们由可变的 80 kDa 亚基和不变的 30 kDa 亚基组成。这种钙蛋白酶似乎具有蛋白酶活性和钙结合能力。一种类似的小鼠蛋白可能在精子发生和减数分裂期间调节钙依赖性信号转导事件中发挥功能性作用。[RefSeq 提供,2008 年 12 月]

Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]

CAPN11 基因产物(1)

mRNA Protein Name
NM_007058.4 NP_008989.2 calpain-11

CAPN11 蛋白结构

Peptidase_C2

Peptidase_C2: Calpain family cysteine protease (79 - 378)

Calpain_III

Calpain_III: Calpain large subunit, domain III (390 - 546)

EF-hand_8

EF-hand_8: EF-hand domain pair (600 - 641)

  • 0
  • 200
  • 400
  • 600
  • 739 a.a.
蛋白主名 其他名称

calpain-11

CANP 11

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CAPN11 VGNC VGNC:70531
Mus musculus CAPN11 MGD MGI:1352490
Felis catus CAPN11 VGNC VGNC:60350
Rattus norvegicus CAPN11 RGD RGD:1302946
Canis familiaris CAPN11 VGNC VGNC:38700
Bos taurus CAPN11 VGNC VGNC:26742