2. Gene
  3. Asic1 - acid-sensing (proton-gated) ion channel 1 Gene

Asic1 - acid-sensing (proton-gated) ion channel 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ASIC; Accn2; BNaC2; ASIC1a; ASIC1b; B530003N02Rik

基因 ID: 11419 | 基因类型: protein coding

关于 Asic1

功能概要

Enables acid-sensing ion channel activity and ion gated channel activity. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and response to amphetamine. Located in synapse. Is integral component of plasma membrane. Is expressed in several structures, including brain. Orthologous to human ASIC1 (acid sensing ion channel subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Asic1 基因产物(2)

mRNA Protein Name
NM_001289791.2 NP_001276720.1 acid-sensing ion channel 1 isoform 2
NM_009597.2 NP_033727.1 acid-sensing ion channel 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables monoatomic cation channel activity IDA
IDA: 通过直接分析推断
11854527 MGI
enables monoatomic cation channel activity IMP
IMP: 通过突变表型推断
11854527 MGI
enables monoatomic ion-gated channel activity IDA
IDA: 通过直接分析推断
14960591 MGI
enables monoatomic ion-gated channel activity IMP
IMP: 通过突变表型推断
14960591 MGI
enables pH-gated monoatomic ion channel activity IDA
IDA: 通过直接分析推断
21036899 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18287010 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within associative learning IMP
IMP: 通过突变表型推断
11988176 MGI
acts upstream of or within behavioral fear response IMP
IMP: 通过突变表型推断
25828470 MGI
acts upstream of or within calcium ion transmembrane transport IMP
IMP: 通过突变表型推断
19376200 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: 通过突变表型推断
14960591 MGI
acts upstream of or within memory IMP
IMP: 通过突变表型推断
11988176 MGI
acts upstream of or within monoatomic cation transport IDA
IDA: 通过直接分析推断
11854527 MGI
acts upstream of or within monoatomic cation transport IMP
IMP: 通过突变表型推断
11854527 MGI
acts upstream of or within monoatomic ion transmembrane transport IDA
IDA: 通过直接分析推断
14960591 MGI
acts upstream of or within monoatomic ion transmembrane transport IMP
IMP: 通过突变表型推断
14960591 MGI
acts upstream of or within negative regulation of neurotransmitter secretion IMP
IMP: 通过突变表型推断
18094106 MGI
acts upstream of neurotransmitter secretion IMP
IMP: 通过突变表型推断
18094106 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: 通过突变表型推断
19376200 MGI
involved in regulation of postsynapse assembly IDA
IDA: 通过直接分析推断
17060608 MGI
involved in regulation of postsynapse assembly IMP
IMP: 通过突变表型推断
17060608 MGI
acts upstream of or within response to acidic pH IDA
IDA: 通过直接分析推断
11854527 MGI
acts upstream of or within response to acidic pH IMP
IMP: 通过突变表型推断
11854527 MGI
acts upstream of or within response to amphetamine IMP
IMP: 通过突变表型推断
25828470 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
17060608 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
17060608 MGI
is active in plasma membrane IDA
IDA: 通过直接分析推断
21036899 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
11854527 MGI
located in synapse IDA
IDA: 通过直接分析推断
11988176 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

acid-sensing ion channel 1

amiloride-sensitive cation channel 2, neuronal

brain sodium channel 2

degenerin 2

相关产品

Pre-clinical Phase
生物活性分子 (18)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P1411 Psalmotoxin 1 99.02% 否
HY-131879 NS383 99.83% 否
HY-N7144A Citronellyl acetate Inhibitor 98.0% 否
HY-P5174 MitTx Activator 98.0% 否
HY-164284 LK-2 Antagonist 98.83% 否
HY-176550 ASIC1a antagonist-1 Antagonist 98.00% 否
HY-P1411A Psalmotoxin 1 TFA 99.37% 否
HY-P1441A Mambalgin 1 TFA Inhibitor 95.72% 否
HY-131261 Ibuprofen alcohol / 否
HY-155017 6-Iodoamiloride Inhibitor / 否
HY-P10977 Tat-ASIC1a (1-20) (mouse, rat) Inhibitor / 否
HY-P5172 MitTx-alpha Agonist / 否
HY-P5780 π-TRTX-Hm3a Inhibitor / 否
HY-P5899 Mambalgin-3 Inhibitor / 否
HY-RS01089 ASIC1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W703632 2-(4-Isobutylphenyl)propan-3,3,3-d3-1-ol / 否
HY-RS17600 Asic1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24060 Asic1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Asic1 NCBI NCBI:41
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