2. Gene
  3. Acox1 - acyl-Coenzyme A oxidase 1, palmitoyl Gene

Acox1 - acyl-Coenzyme A oxidase 1, palmitoyl Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: AOX; Acox; Paox; D130055E20Rik

基因 ID: 11430 | 基因类型: protein coding

关于 Acox1

功能概要

This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-coenzyme A to 2-trans-enoyl-coenzyme A. Disruption of this gene results in microvesicular steatohepatitis, spontaneous peroxisome proliferation, and the eventual development of hepatocellular carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Acox1 基因产物(5)

mRNA Protein Name
NM_001271898.2 NP_001258827.1 peroxisomal acyl-coenzyme A oxidase 1 isoform 2
NM_001377521.1 NP_001364450.1 peroxisomal acyl-coenzyme A oxidase 1 isoform 3
NM_001377522.1 NP_001364451.1 peroxisomal acyl-coenzyme A oxidase 1 isoform 4
NM_015729.4 NP_056544.2 peroxisomal acyl-coenzyme A oxidase 1 isoform 1
NM_001377521.1 NP_001364450.1 peroxisomal acyl-coenzyme A oxidase 1 isoform 3
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in fatty acid oxidation IMP
IMP: 通过突变表型推断
20195242 MGI
acts upstream of or within spermatogenesis IMP
IMP: 通过突变表型推断
8798738 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11156684 MGI
located in peroxisomal membrane IDA
IDA: 通过直接分析推断
12915479 MGI
located in peroxisome IDA
IDA: 通过直接分析推断
17881773 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

peroxisomal acyl-coenzyme A oxidase 1

palmitoyl-CoA oxidase

peroxisomal fatty acyl-CoA oxidase

peroxisomal fatty acyl-coenzyme A oxidase

peroxisomal straight-chain Acyl-CoA oxidase

straight-chain acyl-CoA oxidase

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-135425 10,12-Tricosadiynoic acid Inhibitor 99.95% 否
HY-N1966 (E)-Osmundacetone 99.88% 否
HY-RS00182 ACOX1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17057 Acox1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23501 Acox1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Acox1 NCBI NCBI:51
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