2. Gene
  3. FCRL3 - Fc receptor like 3 Gene

FCRL3 - Fc receptor like 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Fc 受体样 3

种属: Homo sapiens

同用名: FCRH3; IFGP3; IRTA3; SPAP2; CD307c

基因 ID: 115352 | 基因类型: protein coding

关于 FCRL3

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:157,676,481-157,700,956 (from NCBI)

This gene has 12 transcripts (splice variants), 55 orthologues and 17 paralogues. Biased expression in lymph node (RPKM 31.5), spleen (RPKM 20.4) and 2 other tissues.

功能概要

该基因编码免疫球蛋白受体超家族的一个成员，是聚集在 1 号染色体长臂上的几种 Fc 受体样糖蛋白之一。编码的蛋白质在其细胞质结构域中包含免疫受体-酪氨酸激活基序和免疫受体-酪氨酸抑制基序，并且可能在免疫系统的调节中发挥作用。该基因的突变与类风湿性关节炎、自身免疫性甲状腺疾病和系统性红斑狼疮有关。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 2 月]

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

FCRL3 基因产物(2)

mRNA Protein Name
NM_001320333.2 NP_001307262.1 Fc receptor-like protein 3 isoform 3 precursor
NM_052939.4 NP_443171.2 Fc receptor-like protein 3 isoform 1 precursor

FCRL3 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (28 - 90)

Ig_2

Ig_2: Immunoglobulin domain (108 - 185)

Ig_2

Ig_2: Immunoglobulin domain (192 - 271)

Ig_2

Ig_2: Immunoglobulin domain (292 - 376)

Ig_3

Ig_3: Immunoglobulin domain (383 - 451)

Ig_3

Ig_3: Immunoglobulin domain (475 - 548)

  • 0
  • 200
  • 400
  • 600
  • 734 a.a.
蛋白主名 其他名称

Fc receptor-like protein 3

Fc receptor homolog 3

FCRL3 抗体

目录号 产品名 应用 反应物种
HY-P84737 CD307C Antibody (YA4434) WB, FC, ELISA Human
HY-P84737A CD307C Antibody (YA4434)(PBS only) WB, FC, ELISA Human

关联疾病

疾病名称 别名
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Graves' Disease

Graves Disease

Exophthalmic Goiter

Basedow'S Disease

Grave'S Disease

Basedow Disease

Toxic Diffuse Goiter

Graves' Hyperthyroidism

Parry Disease

Autoimmune Hyperthyroidism

Toxic Multinodular Goiter
Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease
Immunodeficiency 48

Combined Immunodeficiency Due To Zap70 Deficiency

IMD48

Selective T-Cell Defect

Stcd

Zeta-Associated-Protein 70 Deficiency

Severe Combined Immunodeficiency, Atypical

Immunodeficiency, Type 48

Zap70 Deficiency
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Autoimmune Pancreatitis

Lymphoplasmocytic Sclerosing Pancreatitis

Aip
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04844 FCRL3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25681 Fcrl5 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus FCRL3 VGNC VGNC:50048
Felis catus FCRL3 VGNC VGNC:62215
Macaca mulatta FCRL3 VGNC VGNC:99949
Mus musculus FCRL3 MGD MGI:3053558
Others FCRL3 NCBI
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