2. Gene
  3. SPPL3 - signal peptide peptidase like 3 Gene

SPPL3 - signal peptide peptidase like 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：信号肽肽酶样 3

种属: Homo sapiens

同用名: IMP2; PSH1; PSL4; PRO4332; MDHV1887

基因 ID: 121665 | 基因类型: protein coding

关于 SPPL3

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,762,510-120,904,358 (from NCBI)

This gene has 9 transcripts (splice variants), 206 orthologues and 4 paralogues. Ubiquitous expression in skin (RPKM 21.6), testis (RPKM 17.3) and 25 other tissues.

功能概要

启用天冬氨酸内肽酶活性、膜内切割和蛋白质同源二聚化活性。参与多个过程，包括 T 细胞受体信号通路；钙调神经磷酸酶-NFAT 信号级联的正调控；和蛋白质去磷酸化的正调节。位于高尔基相关囊泡膜；质膜;和粗面内质网。是内质网膜胞质侧的组成部分和内质网膜腔侧的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of protein dephosphorylation. Located in Golgi-associated vesicle membrane; plasma membrane; and rough endoplasmic reticulum. Is integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

SPPL3 基因产物(1)

mRNA Protein Name
NM_139015.5 NP_620584.2 signal peptide peptidase-like 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aspartic endopeptidase activity, intramembrane cleaving IDA
IDA: 通过直接分析推断
2313285 GOA
enables aspartic endopeptidase activity, intramembrane cleaving IMP
IMP: 通过突变表型推断
16873890 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
2313285 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
15385547 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
25384971 GOA
NOT involved in membrane protein ectodomain proteolysis IMP
IMP: 通过突变表型推断
16829952 GOA
involved in membrane protein proteolysis IDA
IDA: 通过直接分析推断
2313285 GOA
involved in positive regulation of calcineurin-NFAT signaling cascade IMP
IMP: 通过突变表型推断
25384971 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi-associated vesicle membrane IDA
IDA: 通过直接分析推断
16829952 GOA
located in cytoplasmic side of endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
15385547 GOA
located in lumenal side of endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
15385547 GOA
located in membrane IDA
IDA: 通过直接分析推断
2313285 GOA
located in rough endoplasmic reticulum IDA
IDA: 通过直接分析推断
15998642 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPPL3 蛋白结构

Peptidase_A22B

Peptidase_A22B: Signal peptide peptidase (61 - 369)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
蛋白主名 其他名称

signal peptide peptidase-like 3

SPP-like 3

关联疾病

疾病名称 别名
Plasmodium Ovale Malaria

Ovale Malaria

Malariaby Plasmodium Ovale
Sulfonamide Allergy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13707 SPPL3 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SPPL3 VGNC VGNC:80493
Bos taurus SPPL3 VGNC VGNC:35237
Macaca mulatta SPPL3 VGNC VGNC:81578
Rattus norvegicus SPPL3 RGD RGD:1562826
Canis familiaris SPPL3 VGNC VGNC:46761
Mus musculus SPPL3 MGD MGI:1891433
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