1. Gene
  2. Cp - ceruloplasmin Gene

Cp - ceruloplasmin Gene

种属: Mus musculus

同用名: D3Ertd555e

基因 ID: 12870 | 基因类型: protein coding

关于 Cp

功能概要

The protein encoded by this gene is a copper-containing glycoprotein found soluble in the serum and GPI-anchored in Other tissues. It oxidizes Fe(II) to Fe(III) and is proposed to play an important role in iron homeostasis. In humans mutations of this gene cause aceruloplasminemia, which is characterized by retinal degeneration, diabetes, anemia and neurological symptoms. In mouse deficiency of this gene in combination with a deficiency of its homolog hephaestin causes retinal degeneration and serves as a pathophysiological model for aceruloplasminemia and age-related macular degeneration. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]

Cp 基因产物(10)

mRNA Protein Name
NM_001276248.2 NP_001263177.1 ceruloplasmin isoform c precursor
NM_001276250.2 NP_001263179.1 ceruloplasmin isoform c precursor
NM_001374677.1 NP_001361606.1 ceruloplasmin isoform d precursor
NM_001409646.1 NP_001396575.1 ceruloplasmin isoform a precursor
NM_001409647.1 NP_001396576.1 ceruloplasmin isoform a precursor
NM_001409648.1 NP_001396577.1 ceruloplasmin isoform e precursor
NM_001409649.1 NP_001396578.1 ceruloplasmin isoform f precursor
NM_001409650.1 NP_001396579.1 ceruloplasmin isoform g precursor
NM_001409651.1 NP_001396580.1 ceruloplasmin isoform h precursor
NM_007752.4 NP_031778.2 ceruloplasmin isoform b precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables copper ion binding IDA
IDA: 通过直接分析推断
15634671 MGI
enables ferroxidase activity IDA
IDA: 通过直接分析推断
16436657 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
16436657 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

ceruloplasmin

ferroxidase

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cp NCBI NCBI:1356
Canis familiaris Cp NCBI NCBI:442963
Macaca fascicularis Cp NCBI
Susscrofa domestica Cp NCBI
Rattus norvegicus Cp NCBI NCBI:24268
Macaca mulatta Cp NCBI NCBI:712210