2. Gene
  3. Cttn - cortactin Gene

Cttn - cortactin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ems1; 1110020L01Rik

基因 ID: 13043 | 基因类型: protein coding

关于 Cttn

功能概要

Predicted to enable several functions, including Arp2/3 complex binding activity; actin filament binding activity; and profilin binding activity. Involved in intracellular protein transport and regulation of Autophagy of mitochondrion. Acts upstream of or within dendritic spine maintenance; negative regulation of extrinsic apoptotic signaling pathway; and substrate-dependent cell migration, cell extension. Located in several cellular components, including cytoskeleton; lamellipodium; and ruffle. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including 1-cell stage conceptus; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human CTTN (cortactin). [provided by Alliance of Genome Resources, Apr 2022]

Cttn 基因产物(3)

mRNA Protein Name
NM_001252572.2 NP_001239501.1 src substrate cortactin isoform 2
NM_001357116.2 NP_001344045.1 src substrate cortactin isoform 3
NM_007803.6 NP_031829.2 src substrate cortactin isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11018051 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within dendritic spine maintenance IGI
IGI: 通过遗传相互作用推断
23365224 MGI
acts upstream of extrinsic apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
22660580 MGI
involved in intracellular protein transport IMP
IMP: 通过突变表型推断
17959782 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
22660580 MGI
involved in regulation of mitophagy IMP
IMP: 通过突变表型推断
20457763 MGI
acts upstream of or within substrate-dependent cell migration, cell extension IGI
IGI: 通过遗传相互作用推断
19414610 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell cortex IDA
IDA: 通过直接分析推断
12913069 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
12913069 MGI
located in lamellipodium IDA
IDA: 通过直接分析推断
12853475 MGI
located in mitotic spindle midzone IDA
IDA: 通过直接分析推断
22282019 MGI
located in podosome IDA
IDA: 通过直接分析推断
17893324 MGI
located in ruffle IDA
IDA: 通过直接分析推断
10637315 MGI
part of voltage-gated potassium channel complex IDA
IDA: 通过直接分析推断
17959782 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

src substrate cortactin

mammary tumor and squamous cell carcinoma associated (p80/85 src substrate)

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03350 CTTN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22133 Cttn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28655 Cttn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cttn NCBI NCBI:2017
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