Ddit3 - DNA-damage inducible transcript 3 Gene

种属: Mus musculus

同用名: chop; CHOP10; CHOP-10; gadd153; AltDDIT3

基因 ID: 13198 | 基因类型: protein coding

关于 Ddit3

功能概要

Enables several functions, including cAMP response element binding protein binding activity; protein heterodimerization activity; and transcription regulator inhibitor activity. Involved in several processes, including blood vessel maturation; intrinsic apoptotic signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within ER overload response; negative regulation of fat cell differentiation; and sensory perception of sound. Located in late endosome and nucleus. Part of CHOP-C/EBP complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in myxoid liposarcoma. Orthologous to human DDIT3 (DNA damage inducible transcript 3). [provided by Alliance of Genome Resources, Apr 2022]

Ddit3 基因产物(2)

mRNA	Protein	Name
NM_001290183.1	NP_001277112.1	DNA damage-inducible transcript 3 protein
NM_007837.4	NP_031863.3	DNA damage-inducible transcript 3 protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	15601821	MGI
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	23624402	MGI
enables DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	15601821	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	1547942	MGI
enables cAMP response element binding protein binding	IDA IDA: 通过直接分析推断	23624402	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	10713066	MGI
enables protein heterodimerization activity	IDA IDA: 通过直接分析推断	23624402	MGI
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	1547942	MGI
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	15601821	MGI
enables transcription regulator activator activity	IDA IDA: 通过直接分析推断	10523647	MGI
enables transcription regulator inhibitor activity	IDA IDA: 通过直接分析推断	1547942	MGI
enables transcription regulator inhibitor activity	IGI IGI: 通过遗传相互作用推断	1547942	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within ER overload response	IMP IMP: 通过突变表型推断	11854325	MGI
involved in anterior/posterior axis specification	IDA IDA: 通过直接分析推断	16434966	MGI
involved in apoptotic process	IMP IMP: 通过突变表型推断	22265908	MGI
involved in artery development	IMP IMP: 通过突变表型推断	24530784	MGI
involved in blood vessel maturation	IMP IMP: 通过突变表型推断	22265908	MGI
involved in endoplasmic reticulum unfolded protein response	IDA IDA: 通过直接分析推断	23624402	MGI
acts upstream of or within endoplasmic reticulum unfolded protein response	IMP IMP: 通过突变表型推断	15601821	MGI
involved in establishment of protein localization to mitochondrion	IDA IDA: 通过直接分析推断	14752510	MGI
involved in gene expression	IGI IGI: 通过遗传相互作用推断	24530784	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	23624402	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	11854325	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: 通过突变表型推断	9531536	MGI
involved in intrinsic apoptotic signaling pathway in response to nitrosative stress	IDA IDA: 通过直接分析推断	14752510	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	22242125	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	19752026	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: 通过直接分析推断	16434966	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: 通过突变表型推断	26370079	MGI
involved in negative regulation of determination of dorsal identity	IDA IDA: 通过直接分析推断	16434966	MGI
acts upstream of or within negative regulation of fat cell differentiation	IGI IGI: 通过遗传相互作用推断	22441668	MGI
involved in negative regulation of myoblast differentiation	IMP IMP: 通过突变表型推断	22242125	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	16434966	MGI
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	1547942	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	21159964	MGI
involved in positive regulation of neuron apoptotic process	IMP IMP: 通过突变表型推断	16135078	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: 通过遗传相互作用推断	10523647	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	15601821	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	15601821	MGI
involved in regulation of DNA-templated transcription	IMP IMP: 通过突变表型推断	15775988	MGI
involved in release of sequestered calcium ion into cytosol	IMP IMP: 通过突变表型推断	19752026	MGI
involved in response to endoplasmic reticulum stress	IDA IDA: 通过直接分析推断	19752026	MGI
involved in response to platelet-derived growth factor	IMP IMP: 通过突变表型推断	24530784	MGI
involved in response to starvation	IDA IDA: 通过直接分析推断	22242125	MGI
involved in response to wounding	IMP IMP: 通过突变表型推断	24530784	MGI
acts upstream of or within sensory perception of sound	IGI IGI: 通过遗传相互作用推断	30188326	MGI
involved in vascular associated smooth muscle cell migration	IMP IMP: 通过突变表型推断	24530784	MGI
involved in vascular associated smooth muscle cell proliferation	IMP IMP: 通过突变表型推断	24530784	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CHOP-C/EBP complex	IPI IPI: 通过物理相互作用推断	1547942	MGI
part of RNA polymerase II transcription regulator complex	IPI IPI: 通过物理相互作用推断	10523647	MGI
located in cytoplasm	IDA IDA: 通过直接分析推断	1547942	MGI
located in late endosome	IDA IDA: 通过直接分析推断	23028046	MGI
located in nucleus	IDA IDA: 通过直接分析推断	1547942	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

DNA damage-inducible transcript 3 protein

C/EBP homoologous protein 10	C/EBP zeta
CCAAT/enhancer-binding protein homologous protein	DDIT-3
alternative DDIT3 proteins	c/EBP-homologous protein 10
growth arrest and DNA-damage-inducible protein GADD153

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03614	DDIT3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-183004	NCP26		/	否
HY-RS18059	Ddit3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24534	Ddit3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Ddit3	NCBI	NCBI:1649

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

粤ICP备2021105330号-3

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Ddit3 - DNA-damage inducible transcript 3 Gene

关于 Ddit3

功能概要

Ddit3 基因产物(2)

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Ddit3 - DNA-damage inducible transcript 3 Gene

关于 Ddit3

功能概要

Ddit3 基因产物(2)

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

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