2. Gene
  3. CD109 - CD109 molecule Gene

CD109 - CD109 molecule Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CD109 分子

种属: Homo sapiens

同用名: p180; r150; CPAMD7

基因 ID: 135228 | 基因类型: protein coding

关于 CD109

Cytogenetic location: 6q13 Genomic coordinates (GRCh38): 6:73,679,192-73,828,313 (from NCBI)

This gene has 5 transcripts (splice variants), 227 orthologues, 8 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 9.8), endometrium (RPKM 7.6) and 21 other tissues.

功能概要

该基因编码糖基磷脂酰肌醇 (GPI) 连接的糖蛋白，定位于血小板、活化的 T 细胞和内皮细胞的表面。该蛋白质通过转化生长因子 β (TGF-β) 结合并负向调节信号传导。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2014 年 4 月]

This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

CD109 基因产物(3)

mRNA Protein Name
NM_001159587.3 NP_001153059.1 CD109 antigen isoform 2 preproprotein
NM_001159588.3 NP_001153060.1 CD109 antigen isoform 3 preproprotein
NM_133493.5 NP_598000.2 CD109 antigen isoform 1 preproprotein
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
16754747 GOA
involved in negative regulation of wound healing IDA
IDA: 通过直接分析推断
16754747 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD109 蛋白结构

A2M_N

A2M_N: MG2 domain (131 - 221)

A2M_N_2

A2M_N_2: Alpha-2-macroglobulin family N-terminal region (468 - 599)

A2M

A2M: Alpha-2-macroglobulin family (693 - 782)

Thiol-ester_cl

Thiol-ester_cl: Alpha-macro-globulin thiol-ester bond-forming region (910 - 940)

A2M_comp

A2M_comp: A-macroglobulin complement component (959 - 1195)

A2M_recep

A2M_recep: A-macroglobulin receptor (1311 - 1395)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1445 a.a.
蛋白主名 其他名称

CD109 antigen

150 kDa TGF-beta-1-binding protein

CD109 抗体

目录号 产品名 应用 反应物种
HY-P84647 CD109 Antibody (YA4344) IHC-P, ICC/IF, FC, ELISA Human
HY-P84647A CD109 Antibody (YA4344)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

关联疾病

疾病名称 别名
Fetal And Neonatal Alloimmune Thrombocytopenia

Nait

Neonatal Alloimmune Thrombocytopenia

Fnait
Adenosquamous Gallbladder Carcinoma

Adenosquamous Carcinoma Of Gallbladder

Adenosquamous Carcinoma Of The Gallbladder

Gallbladder Adenosquamous Carcinoma
Gallbladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Gallbladder

Epidermoid Gallbladder Carcinoma
Immunodeficiency 15b

IMD15B

Immunodeficiency, Type 15b
Myxofibrosarcoma

Fibromyxosarcoma

Fibromyxoid Sarcoma

Myxoid Malignant Fibrous Histiocytoma

Dermatofibrosarcoma Protuberans, Myxoid
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02188 CD109 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19660 Cd109 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26153 Cd109 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CD109 VGNC VGNC:38929
Felis catus CD109 VGNC VGNC:60583
Bos taurus CD109 VGNC VGNC:27002
Mus musculus CD109 MGD MGI:2445221
Rattus norvegicus CD109 RGD RGD:1311287
Macaca mulatta CD109 VGNC VGNC:70834
Others CD109 NCBI
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