2. Gene
  3. Fgr - FGR proto-oncogene, Src family tyrosine kinase Gene

Fgr - FGR proto-oncogene, Src family tyrosine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ali18; Mhdaali18

基因 ID: 14191 | 基因类型: protein coding

关于 Fgr

功能概要

Enables several functions, including immunoglobulin receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphotyrosine residue binding activity. Involved in several processes, including defense response to Gram-positive bacterium; integrin-mediated signaling pathway; and regulation of vesicle-mediated transport. Acts upstream of or within bone mineralization and skeletal system morphogenesis. Located in plasma membrane. Colocalizes with actin Cytoskeleton and ruffle membrane. Is expressed in 2-cell stage embryo; blastocyst; nervous system; and neural ectoderm. Orthologous to human FGR (FGR proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Fgr 基因产物(1)

mRNA Protein Name
NM_010208.4 NP_034338.3 tyrosine-protein kinase Fgr
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables immunoglobulin receptor binding IDA
IDA: 通过直接分析推断
21746961 MGI
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
15561106 MGI
enables phosphotyrosine residue binding IDA
IDA: 通过直接分析推断
11672534 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16439675 MGI
enables protein kinase binding IDA
IDA: 通过直接分析推断
11672534 MGI
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
11672534 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within bone mineralization IMP
IMP: 通过突变表型推断
16964445 MGI
acts upstream of or within defense response to Gram-positive bacterium IGI
IGI: 通过遗传相互作用推断
8125254 MGI
involved in defense response to Gram-positive bacterium IMP
IMP: 通过突变表型推断
8125254 MGI
involved in integrin-mediated signaling pathway IMP
IMP: 通过突变表型推断
11672534 MGI
involved in negative regulation of natural killer cell activation IMP
IMP: 通过突变表型推断
16439675 MGI
involved in peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
15561106 MGI
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
15561106 MGI
involved in positive regulation of cytokine production IDA
IDA: 通过直接分析推断
21746961 MGI
involved in positive regulation of mast cell degranulation IDA
IDA: 通过直接分析推断
21746961 MGI
involved in regulation of cell shape IMP
IMP: 通过突变表型推断
11672534 MGI
involved in regulation of innate immune response IMP
IMP: 通过突变表型推断
21746961 MGI
involved in regulation of phagocytosis IMP
IMP: 通过突变表型推断
11672534 MGI
involved in regulation of protein kinase activity IDA
IDA: 通过直接分析推断
11672534 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: 通过突变表型推断
16964445 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with actin cytoskeleton IDA
IDA: 通过直接分析推断
15561106 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
15561106 MGI
colocalizes with ruffle membrane IDA
IDA: 通过直接分析推断
15561106 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein kinase Fgr

Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog

p55-Fgr

proto-oncogene c-Fgr

proto-oncogene tyrosine-protein kinase Fgr

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-178014 SIK1-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fgr NCBI NCBI:2268
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