NLRP4 - NLR family pyrin domain containing 4 Gene

中文名称：含 NLR 家族 pyrin 结构域 4

种属: Homo sapiens

同用名: CT58; PAN2; RNH2; NALP4; PYPAF4; CLR19.5

关于 NLRP4

功能概要

由该基因编码的蛋白质是核苷酸结合和富含亮氨酸重复受体 (NLR) 家族的成员，预计含有一个 N 端热蛋白效应结构域 (PYD) ，一个位于中心的核苷酸结合和寡聚化结构域结构域 (NACHT) 和 C 端富含亮氨酸的重复序列 (LRR) 。由于蛋白质与其 NACHT 结构域的相互作用，该基因产物具有作为自噬和 I 型干扰素信号通路负调节剂的作用。 PYD 结构域也被证明在抑制 NF-kB (活化 B 细胞的核因子 kappa-轻链增强子) 中很重要。[RefSeq 提供，2016 年 12 月]

The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of Autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016]