Grm1 - glutamate receptor, metabotropic 1 Gene

中文名称：谷氨酸受体，代谢型 1

种属: Mus musculus

同用名: rcw; wobl; Gprc1a; mGluR1; nmf373; Gm10828; 4930455H15Rik

关于 Grm1

功能概要

使 G 蛋白偶联神经递质受体活性参与调节突触后细胞溶质钙离子浓度。参与多个过程，包括 MAPK 级联的正向调节；调节疼痛的感官知觉；和疼痛的感官知觉。在 L-谷氨酸的上游或内部作用于质膜和细胞对电刺激的反应。位于树突中；核;和突触后密度。活跃于 Schaffer 侧支 - CA1 突触和谷氨酸能突触。以多种结构表达，包括附肢骨骼；眼睛;神经系统;睾丸;和舌头。用于研究常染色体隐性脊髓小脑性共济失调 13；皮肤黑色素瘤;和葡萄膜黑色素瘤。该基因的人类直系同源基因与常染色体隐性遗传脊髓小脑性共济失调 13 和脊髓小脑性共济失调 44 相关。与人类 GRM1（谷氨酸代谢受体 1）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Involved in several processes, including positive regulation of MAPK cascade; regulation of sensory perception of pain; and sensory perception of pain. Acts upstream of or within L-glutamate import across plasma membrane and cellular response to electrical stimulus. Located in dendrite; nucleus; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including appendicular skeleton; eye; nervous system; testis; and tongue. Used to study autosomal recessive spinocerebellar ataxia 13; skin melanoma; and uveal melanoma. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1). [provided by Alliance of Genome Resources, Apr 2022]