1. Gene
  2. DCST1 - DC-STAMP domain containing 1 Gene

DCST1 - DC-STAMP domain containing 1 Gene

中文名称:含 DC-STAMP 域 1

种属: Homo sapiens

同用名: SNKY; SPE49

基因 ID: 149095 | 基因类型: protein coding

关于 DCST1

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:155,033,806-155,050,930 (from NCBI)

This gene has 5 transcripts (splice variants), 178 orthologues and 3 paralogues. Biased expression in testis (RPKM 2.9), skin (RPKM 1.8) and 8 other tissues.

功能概要

该基因编码的蛋白质具有与树突状细胞 (PMID:11169400) 中发现的结构域相似的结构域,树突状细胞在抗原处理和免疫反应显示中起着关键作用。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2011 年 9 月]

This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key role in antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

DCST1 基因产物(2)

mRNA Protein Name
NM_001143687.2 NP_001137159.1 E3 ubiquitin-protein ligase DCST1 isoform 2
NM_152494.4 NP_689707.2 E3 ubiquitin-protein ligase DCST1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
27782195 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
27782195 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of type I interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
27782195 GOA
involved in ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
27782195 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
27782195 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DCST1 蛋白结构

DC_STAMP

DC_STAMP: DC-STAMP-like protein (405 - 595)

  • 0
  • 200
  • 400
  • 600
  • 706 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase DCST1

DC-STAMP domain-containing protein 1

直系同源

种属 基因名 来源 基因 ID
Felis catus DCST1 VGNC VGNC:61376
Mus musculus DCST1 MGD MGI:1925022
Rattus norvegicus DCST1 RGD RGD:1307756
Macaca mulatta DCST1 VGNC VGNC:71721
Bos taurus DCST1 VGNC VGNC:27923
Canis familiaris DCST1 VGNC VGNC:39812