2. Gene
  3. OGA - Oga O-GlcNAcase Gene

OGA - Oga O-GlcNAcase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Mgea5; Ncoat

基因 ID: 154968 | 基因类型: protein coding

关于 OGA

功能概要

Enables beta-N-acetylglucosaminidase activity and Histone Acetyltransferase activity. Involved in several processes, including positive regulation of mitochondrial depolarization; positive regulation of transport; and regulation of cellular protein metabolic process. Located in mitochondrion. Orthologous to human OGA (O-GlcNAcase). [provided by Alliance of Genome Resources, Apr 2022]

OGA 基因产物(1)

mRNA Protein Name
NM_131904.2 NP_571979.1 protein O-GlcNAcase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables beta-N-acetylglucosaminidase activity IDA
IDA: 通过直接分析推断
19004814 RGD
enables histone acetyltransferase activity IMP
IMP: 通过突变表型推断
15485860 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in N-acetylglucosamine metabolic process IMP
IMP: 通过突变表型推断
19139380 RGD
involved in dATP metabolic process IMP
IMP: 通过突变表型推断
17573462 RGD
involved in negative regulation of cardiac muscle adaptation IMP
IMP: 通过突变表型推断
17573462 RGD
involved in negative regulation of protein glycosylation IMP
IMP: 通过突变表型推断
16332679 RGD
involved in positive regulation of D-glucose import IMP
IMP: 通过突变表型推断
16000877 RGD
involved in positive regulation of DNA metabolic process IMP
IMP: 通过突变表型推断
19139380 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
16899550 RGD
involved in positive regulation of calcium ion transport IMP
IMP: 通过突变表型推断
19139380 RGD
involved in positive regulation of calcium ion transport into cytosol IMP
IMP: 通过突变表型推断
16107505 RGD
involved in positive regulation of cell killing IMP
IMP: 通过突变表型推断
19139380 RGD
involved in positive regulation of growth hormone secretion IMP
IMP: 通过突变表型推断
12242036 RGD
involved in positive regulation of insulin secretion IMP
IMP: 通过突变表型推断
17095531 RGD
involved in positive regulation of mitochondrial depolarization IMP
IMP: 通过突变表型推断
19139380 RGD
involved in positive regulation of protein-containing complex disassembly IMP
IMP: 通过突变表型推断
17573462 RGD
involved in positive regulation of proteolysis IMP
IMP: 通过突变表型推断
17573462 RGD
involved in protein targeting to membrane IMP
IMP: 通过突变表型推断
16000877 RGD
involved in response to steroid hormone IEP
IEP: 通过表达模式推断
19139380 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein O-GlcNAcase

N-acetyl-beta-D-glucosaminidase

N-acetyl-beta-glucosaminidase

beta-N-acetylhexosaminidase

beta-hexosaminidase

bifunctional protein NCOAT

meningioma expressed antigen 5 (hyaluronidase)

meningioma-expressed antigen 5

nuclear cytoplasmic O-GlcNAcase a

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-144681 Ceperognastat Inhibitor 99.09% Phase 2
HY-130121 MK-8719 99.55% Phase 1
Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12588 Thiamet G Inhibitor 99.99% 否
HY-108241 (Z)-PUGNAc 99.13% 否
HY-156586 Egalognastat Inhibitor 99.03% 否
HY-139431 NAG-thiazoline Inhibitor ≥95.0% 否
HY-108032 Hydroxyectoin Inhibitor 98.0% 否
HY-131979 TP-040 98.59% 否
HY-144682 (2R,4R)-LY3372689 / 否
HY-144681A rel-Ceperognastat Inhibitor / 否
HY-148240 JNJ-65355394 Inhibitor / 否
HY-161953 O-GlcNAcase-IN-2 Inhibitor / 否
HY-181600 O-GlcNAcase-IN-4 Inhibitor / 否
HY-176852 O-GlcNAcase-IN-3 Inhibitor / 否
HY-185146 O-GlcNAcase-IN-5 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens OGA NCBI NCBI:10724
Canis familiaris OGA NCBI NCBI:477802
Mus musculus OGA NCBI NCBI:76055
Susscrofa domestica OGA NCBI
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