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  3. Itpr2 - inositol 1,4,5-triphosphate receptor 2 Gene

Itpr2 - inositol 1,4,5-triphosphate receptor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ip3r2; Itpr5; insP3R2; InsP3R-2; InsP3R-5

基因 ID: 16439 | 基因类型: protein coding

关于 Itpr2

功能概要

Enables inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity and phosphatidylinositol binding activity. Involved in cellular response to cAMP. Acts upstream of or within calcium ion transport and cellular response to ethanol. Located in cell cortex and sarcoplasmic reticulum. Is expressed in several structures, including heart; liver; medulla oblongata; skeletal muscle; and spleen. Used to study isolated anhidrosis with normal sweat glands. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and isolated anhidrosis with normal sweat glands. Orthologous to human ITPR2 (inositol 1,4,5-trisphosphate receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

Itpr2 基因产物(2)

mRNA Protein Name
NM_010586.2 NP_034716.1 inositol 1,4,5-trisphosphate receptor type 2 isoform 2
NM_019923.4 NP_064307.2 inositol 1,4,5-trisphosphate receptor type 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables inositol 1,4,5-trisphosphate-gated calcium channel activity IDA
IDA: 通过直接分析推断
8063813 MGI
enables intracellularly gated calcium channel activity IDA
IDA: 通过直接分析推断
8063813 MGI
enables phosphatidylinositol binding IDA
IDA: 通过直接分析推断
8063813 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
21424589 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within calcium ion transport IDA
IDA: 通过直接分析推断
8063813 MGI
involved in cellular response to cAMP IDA
IDA: 通过直接分析推断
20189985 MGI
acts upstream of or within cellular response to ethanol IMP
IMP: 通过突变表型推断
21436055 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell cortex IDA
IDA: 通过直接分析推断
9858485 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
9858485 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
15632133 MGI
located in sarcoplasmic reticulum IDA
IDA: 通过直接分析推断
16014380 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

inositol 1,4,5-trisphosphate receptor type 2

IP3 receptor

IP3R 2

inositol 1,4,5-triphosphate receptor 5

inositol 1,4,5-trisphosphate type V receptor

inositol trisphosphate receptor type 2

type 2 InsP3 receptor

type 2 inositol 1,4,5-trisphosphate receptor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06992 ITPR2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20971 Itpr2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27488 Itpr2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Itpr2 NCBI NCBI:3709
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