2. Gene
  3. Sh2b3 - SH2B adaptor protein 3 Gene

Sh2b3 - SH2B adaptor protein 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Lnk

基因 ID: 16923 | 基因类型: protein coding

关于 Sh2b3

功能概要

This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and Apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Sh2b3 基因产物(4)

mRNA Protein Name
NM_001306126.2 NP_001293055.1 SH2B adapter protein 3 isoform 1
NM_001306127.2 NP_001293056.1 SH2B adapter protein 3 isoform 1
NM_001306128.2 NP_001293057.1 SH2B adapter protein 3 isoform 2
NM_008507.5 NP_032533.1 SH2B adapter protein 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11805142 MGI
enables protein tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
14612394 MGI
enables signaling receptor complex adaptor activity IPI
IPI: 通过物理相互作用推断
14612394 MGI
enables stem cell factor receptor binding IDA
IDA: 通过直接分析推断
14612394 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within negative effect cellular response to chemokine IMP
IMP: 通过突变表型推断
15337790 MGI
involved in cellular response to interleukin-3 IDA
IDA: 通过直接分析推断
15337790 MGI
acts upstream of or within embryonic hemopoiesis IDA
IDA: 通过直接分析推断
14612394 MGI
acts upstream of negative effect embryonic hemopoiesis IMP
IMP: 通过突变表型推断
14612394 MGI
acts upstream of or within embryonic hemopoiesis IMP
IMP: 通过突变表型推断
14612394 MGI
acts upstream of or within hematopoietic stem cell differentiation IMP
IMP: 通过突变表型推断
14612394 MGI
acts upstream of or within hemopoiesis IMP
IMP: 通过突变表型推断
11805142 MGI
acts upstream of or within intracellular signal transduction IDA
IDA: 通过直接分析推断
11805142 MGI
involved in megakaryocyte development IMP
IMP: 通过突变表型推断
15337790 MGI
involved in monocyte homeostasis IGI
IGI: 通过遗传相互作用推断
27430239 MGI
involved in negative regulation of Kit signaling pathway IMP
IMP: 通过突变表型推断
14612394 MGI
involved in negative regulation of MAPK cascade IMP
IMP: 通过突变表型推断
15337790 MGI
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
15337790 MGI
involved in negative regulation of chemokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
15337790 MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
15337790 MGI
involved in negative regulation of platelet aggregation IGI
IGI: 通过遗传相互作用推断
27430239 MGI
involved in negative regulation of receptor signaling pathway via STAT IMP
IMP: 通过突变表型推断
15337790 MGI
involved in neutrophil homeostasis IGI
IGI: 通过遗传相互作用推断
27430239 MGI
acts upstream of negative effect thrombopoietin-mediated signaling pathway IGI
IGI: 通过遗传相互作用推断
27430239 MGI
involved in thrombopoietin-mediated signaling pathway IMP
IMP: 通过突变表型推断
15337790 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

SH2B adapter protein 3

linker of T-cell receptor pathways

lymphocyte-specific adapter protein Lnk

signal transduction protein Lnk

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12820 SH2B3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22804 Sh2b3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29318 Sh2b3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sh2b3 NCBI NCBI:10019
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