2. Gene
  3. Ascl2 - achaete-scute family bHLH transcription factor 2 Gene

Ascl2 - achaete-scute family bHLH transcription factor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Mash2; bHLHa45; 2410083I15Rik

基因 ID: 17173 | 基因类型: protein coding

关于 Ascl2

功能概要

Enables sequence-specific DNA binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II; somatic stem cell population maintenance; and spongiotrophoblast differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and musculoskeletal system. Orthologous to human ASCL2 (achaete-scute family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ascl2 基因产物(1)

mRNA Protein Name
NM_008554.3 NP_032580.2 achaete-scute homolog 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10611232 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IGI
IGI: 通过遗传相互作用推断
10611232 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
24463518 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IGI
IGI: 通过遗传相互作用推断
10611232 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
24463518 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IGI
IGI: 通过遗传相互作用推断
25620640 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: 通过突变表型推断
25620640 MGI
enables bHLH transcription factor binding IPI
IPI: 通过物理相互作用推断
10611232 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
9676199 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within T cell differentiation IMP
IMP: 通过突变表型推断
31539517 MGI
involved in T follicular helper cell differentiation IMP
IMP: 通过突变表型推断
24463518 MGI
acts upstream of or within cell differentiation IMP
IMP: 通过突变表型推断
8090202 MGI
involved in chorionic trophoblast cell development IMP
IMP: 通过突变表型推断
7773285 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
8090202 MGI
involved in negative regulation of T-helper 1 cell differentiation IMP
IMP: 通过突变表型推断
24463518 MGI
involved in negative regulation of T-helper 17 cell differentiation IMP
IMP: 通过突变表型推断
24463518 MGI
involved in negative regulation of T-helper 2 cell differentiation IMP
IMP: 通过突变表型推断
24463518 MGI
involved in negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
10611232 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
24463518 MGI
acts upstream of or within placenta development IMP
IMP: 通过突变表型推断
21238448 MGI
involved in positive regulation of T cell migration IMP
IMP: 通过突变表型推断
24463518 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10611232 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
10611232 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
24463518 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19796622 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
9676199 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: 通过突变表型推断
19269367 MGI
acts upstream of or within spongiotrophoblast differentiation IMP
IMP: 通过突变表型推断
9331331 MGI
involved in stem cell population maintenance IMP
IMP: 通过突变表型推断
25620640 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
23372768 MGI
located in nucleus IDA
IDA: 通过直接分析推断
19269367 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

achaete-scute homolog 2

ASH-2

achaete-scute complex homolog 2

achaete-scute complex homolog-like 2

long transient receptor potential-related channel 5

mASH-2

mammalian achaete scute homolog 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01079 ASCL2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20860 Ascl2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27375 Ascl2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ascl2 NCBI NCBI:430
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