2. Gene
  3. Msh6 - mutS homolog 6 Gene

Msh6 - mutS homolog 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: GTBP; Gtmbp

基因 ID: 17688 | 基因类型: protein coding

关于 Msh6

功能概要

Enables chromatin binding activity; damaged DNA binding activity; and guanine/thymine mispair binding activity. Acts upstream of or within several processes, including determination of adult lifespan; intrinsic apoptotic signaling pathway in response to DNA damage; and somatic diversification of immunoglobulins. Located in chromatin. Part of MutSalpha complex. Is expressed in several structures, including brain; early conceptus; liver; lung; and oocyte. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; hereditary nonpolyposis colorectal Cancer type 5; and mismatch repair Cancer syndrome. Orthologous to human MSH6 (mutS homolog 6). [provided by Alliance of Genome Resources, Apr 2022]

Msh6 基因产物(1)

mRNA Protein Name
NM_010830.2 NP_034960.1 DNA mismatch repair protein Msh6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IGI
IGI: 通过遗传相互作用推断
10545954 MGI
enables DNA binding IMP
IMP: 通过突变表型推断
10545954 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
16618598 MGI
enables damaged DNA binding IGI
IGI: 通过遗传相互作用推断
10545954 MGI
enables damaged DNA binding IMP
IMP: 通过突变表型推断
10545954 MGI
contributes to guanine/thymine mispair binding IDA
IDA: 通过直接分析推断
16713580 MGI
enables guanine/thymine mispair binding IDA
IDA: 通过直接分析推断
15324697 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within determination of adult lifespan IMP
IMP: 通过突变表型推断
9390556 MGI
acts upstream of or within intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
14632208 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
15324697 MGI
acts upstream of or within isotype switching IGI
IGI: 通过遗传相互作用推断
17015724 MGI
acts upstream of or within isotype switching IMP
IMP: 通过突变表型推断
16618598 MGI
acts upstream of or within mismatch repair IGI
IGI: 通过遗传相互作用推断
11691815 MGI
acts upstream of or within mismatch repair IMP
IMP: 通过突变表型推断
9390556 MGI
acts upstream of or within negative regulation of DNA recombination IMP
IMP: 通过突变表型推断
10545954 MGI
acts upstream of or within response to UV IMP
IMP: 通过突变表型推断
14632208 MGI
acts upstream of or within somatic hypermutation of immunoglobulin genes IMP
IMP: 通过突变表型推断
10662804 MGI
acts upstream of or within somatic recombination of immunoglobulin gene segments IMP
IMP: 通过突变表型推断
15238604 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of MutSalpha complex IDA
IDA: 通过直接分析推断
16713580 MGI
located in chromatin IDA
IDA: 通过直接分析推断
16618598 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

DNA mismatch repair protein Msh6

g/T mismatch-binding protein

mutS protein homolog 6

mutS-alpha 160 kDa subunit

p160

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08713 MSH6 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22241 Msh6 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28763 Msh6 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Msh6 NCBI NCBI:2956
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