2. Gene
  3. Msx2 - msh homeobox 2 Gene

Msx2 - msh homeobox 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Hox8; Hox-8; Hox8.1

基因 ID: 17702 | 基因类型: protein coding

关于 Msx2

功能概要

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription regulatory region DNA binding activity; negative regulation of transcription, DNA-templated; and osteoblast differentiation. Acts upstream of or within several processes, including animal organ development; embryonic limb morphogenesis; and regulation of gene expression. Part of transcription regulator complex. Is expressed in several structures, including embryo ectoderm; embryo mesenchyme; genitourinary system; jaw; and sensory organ. Used to study craniosynostosis and parietal foramina. Human ortholog(s) of this gene implicated in craniosynostosis and parietal foramina. Orthologous to human MSX2 (msh homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Msx2 基因产物(1)

mRNA Protein Name
NM_013601.2 NP_038629.2 homeobox protein MSX-2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
9265625 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
8861098 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
8861098 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
20843790 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: 通过突变表型推断
8861098 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10451362 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
15383550 MGI
enables transcription factor binding IDA
IDA: 通过直接分析推断
9265625 MGI
enables transcription factor binding IPI
IPI: 通过物理相互作用推断
9265625 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within BMP signaling pathway IDA
IDA: 通过直接分析推断
18590716 MGI
acts upstream of BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
18667074 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
17601530 MGI
acts upstream of or within activation of meiosis IPI
IPI: 通过物理相互作用推断
22071108 MGI
acts upstream of or within anagen IMP
IMP: 通过突变表型推断
11744114 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: 通过遗传相互作用推断
21465616 MGI
acts upstream of or within bone morphogenesis IGI
IGI: 通过遗传相互作用推断
17693062 MGI
acts upstream of or within bone trabecula formation IMP
IMP: 通过突变表型推断
10742104 MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis IMP
IMP: 通过突变表型推断
10742104 MGI
acts upstream of or within cartilage development IMP
IMP: 通过突变表型推断
10742104 MGI
acts upstream of catagen IMP
IMP: 通过突变表型推断
10742104 MGI
acts upstream of or within cell surface receptor signaling pathway involved in heart development IGI
IGI: 通过遗传相互作用推断
18667074 MGI
acts upstream of or within cellular response to estradiol stimulus IDA
IDA: 通过直接分析推断
8787747 MGI
acts upstream of or within cellular response to growth factor stimulus IDA
IDA: 通过直接分析推断
7848824 MGI
acts upstream of or within chondrocyte development IMP
IMP: 通过突变表型推断
10742104 MGI
acts upstream of or within embryonic digit morphogenesis IGI
IGI: 通过遗传相互作用推断
21465616 MGI
acts upstream of or within embryonic forelimb morphogenesis IGI
IGI: 通过遗传相互作用推断
21465616 MGI
acts upstream of or within embryonic hindlimb morphogenesis IGI
IGI: 通过遗传相互作用推断
21465616 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: 通过遗传相互作用推断
15930102 MGI
acts upstream of or within embryonic nail plate morphogenesis IGI
IGI: 通过遗传相互作用推断
21465616 MGI
acts upstream of or within enamel mineralization IMP
IMP: 通过突变表型推断
10742104 MGI
acts upstream of or within endochondral bone growth IMP
IMP: 通过突变表型推断
10742104 MGI
acts upstream of or within epithelial to mesenchymal transition involved in endocardial cushion formation IGI
IGI: 通过遗传相互作用推断
18667074 MGI
acts upstream of or within frontal suture morphogenesis IMP
IMP: 通过突变表型推断
10742104 MGI
acts upstream of or within mammary gland epithelium development IGI
IGI: 通过遗传相互作用推断
10742104 MGI
acts upstream of mesenchymal cell apoptotic process IGI
IGI: 通过遗传相互作用推断
19422820 MGI
acts upstream of or within negative regulation of CREB transcription factor activity IDA
IDA: 通过直接分析推断
15175325 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15383550 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: 通过遗传相互作用推断
17601530 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
17601530 MGI
acts upstream of or within negative regulation of fat cell differentiation IDA
IDA: 通过直接分析推断
15175325 MGI
acts upstream of or within negative regulation of keratinocyte differentiation IMP
IMP: 通过突变表型推断
19769717 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9265625 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8861098 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
17030628 MGI
acts upstream of or within negative regulation of transcription regulatory region DNA binding IDA
IDA: 通过直接分析推断
15175325 MGI
acts upstream of or within odontogenesis IMP
IMP: 通过突变表型推断
10742104 MGI
acts upstream of or within ossification IMP
IMP: 通过突变表型推断
10742104 MGI
acts upstream of or within osteoblast development IMP
IMP: 通过突变表型推断
10742104 MGI
involved in osteoblast differentiation IDA
IDA: 通过直接分析推断
15383550 MGI
acts upstream of or within outflow tract morphogenesis IGI
IGI: 通过遗传相互作用推断
17601530 MGI
acts upstream of or within outflow tract septum morphogenesis IGI
IGI: 通过遗传相互作用推断
17601530 MGI
acts upstream of or within positive regulation of BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
18667074 MGI
acts upstream of or within positive regulation of mesenchymal cell apoptotic process IGI
IGI: 通过遗传相互作用推断
19422820 MGI
acts upstream of or within positive regulation of osteoblast differentiation IDA
IDA: 通过直接分析推断
15175325 MGI
acts upstream of or within positive regulation of timing of catagen IMP
IMP: 通过突变表型推断
10742104 MGI
acts upstream of or within regulation of apoptotic process IDA
IDA: 通过直接分析推断
18729207 MGI
acts upstream of or within signal transduction involved in regulation of gene expression IGI
IGI: 通过遗传相互作用推断
21465616 MGI
acts upstream of or within stem cell differentiation IGI
IGI: 通过遗传相互作用推断
17693062 MGI
acts upstream of or within wound healing IMP
IMP: 通过突变表型推断
19769717 MGI
acts upstream of or within wound healing, spreading of epidermal cells IMP
IMP: 通过突变表型推断
19769717 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of transcription regulator complex IPI
IPI: 通过物理相互作用推断
18285513 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

homeobox protein MSX-2

homeo box, msh-like 2

homeobox protein Hox-8-1

homeobox, msh-like 2

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08734 MSX2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-117184 MSX-2 Antagonist / 否
HY-RS21379 Msx2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27898 Msx2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Msx2 NCBI NCBI:4488
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