2. Gene
  3. Pcsk2 - proprotein convertase subtilisin/kexin type 2 Gene

Pcsk2 - proprotein convertase subtilisin/kexin type 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: PC2; Nec2; SPC2; Nec-2; Phpp-2; 6330411F23Rik

基因 ID: 18549 | 基因类型: protein coding

关于 Pcsk2

功能概要

Enables serine-type endopeptidase activity. Involved in enkephalin processing and protein autoprocessing. Acts upstream of or within nervous system development and proteolysis. Located in extracellular space. Is expressed in brain; endocrine gland; future brain; and gut. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Apr 2022]

Pcsk2 基因产物(1)

mRNA Protein Name
NM_008792.4 NP_032818.1 neuroendocrine convertase 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables endopeptidase activity IDA
IDA: 通过直接分析推断
9242664 MGI
enables serine-type endopeptidase activity IDA
IDA: 通过直接分析推断
8262946 MGI
enables serine-type endopeptidase activity IMP
IMP: 通过突变表型推断
9452465 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in enkephalin processing IDA
IDA: 通过直接分析推断
8262946 MGI
involved in insulin processing IMP
IMP: 通过突变表型推断
9452465 MGI
involved in nervous system development IEP
IEP: 通过表达模式推断
16893422 MGI
involved in peptide hormone processing IDA
IDA: 通过直接分析推断
9242664 MGI
acts upstream of or within peptide hormone processing IMP
IMP: 通过突变表型推断
12859669 MGI
involved in protein autoprocessing IDA
IDA: 通过直接分析推断
16893422 MGI
involved in protein processing IDA
IDA: 通过直接分析推断
9242664 MGI
acts upstream of or within proteolysis IMP
IMP: 通过突变表型推断
12859669 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
8397508 MGI
is active in secretory granule IDA
IDA: 通过直接分析推断
9452465 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neuroendocrine convertase 2

KEX2-like endoprotease 2

NEC 2

prohormone convertase 2

proprotein convertase 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10172 PCSK2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21016 Pcsk2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27533 Pcsk2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pcsk2 NCBI NCBI:5126
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