2. Gene
  3. Abcb4 - ATP-binding cassette, sub-family B (MDR/TAP), member 4 Gene

Abcb4 - ATP-binding cassette, sub-family B (MDR/TAP), member 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Mdr2; Pgy2; Pgy-2; mdr-2

基因 ID: 18670 | 基因类型: protein coding

关于 Abcb4

功能概要

Predicted to enable ATPase-coupled intramembrane lipid transporter activity; ATPase-coupled transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in bile acid secretion and response to fenofibrate. Located in intercellular canaliculus and plasma membrane. Is expressed in alimentary system and liver. Used to study cholecystitis; cholestasis; hepatocellular carcinoma; intrahepatic cholestasis; and primary sclerosing cholangitis. Human ortholog(s) of this gene implicated in cholestasis (multiple); gallbladder disease; and liver cirrhosis (multiple). Orthologous to human ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Apr 2022]

Abcb4 基因产物(1)

mRNA Protein Name
NM_008830.2 NP_032856.2 phosphatidylcholine translocator ABCB4
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in bile acid secretion IMP
IMP: 通过突变表型推断
8106172 MGI
involved in response to fenofibrate IDA
IDA: 通过直接分析推断
8615769 MGI
NOT involved in xenobiotic transmembrane transport IDA
IDA: 通过直接分析推断
1990275 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in intercellular canaliculus IDA
IDA: 通过直接分析推断
12068294 MGI
located in membrane IDA
IDA: 通过直接分析推断
11279518 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
8615769 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

phosphatidylcholine translocator ABCB4

ATP-binding cassette sub-family B member 4

P glycoprotein 2

P-glycoprotein 3

multidrug resistance protein 2

multidrug resistance protein 3

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-183032 ABC transporter modulator-1 Activator / 否
HY-183033 ABC transporter modulator-2 Activator / 否
HY-183034 ABC transporter modulator-3 Activator / 否
HY-183035 ABC transporter modulator-4 Modulator / 否
HY-183036 ABC transporter modulator-5 Modulator / 否
HY-RS00051 ABCB4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21466 Abcb4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Abcb4 NCBI NCBI:5244
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