2. Gene
  3. Polb - polymerase (DNA directed), beta Gene

Polb - polymerase (DNA directed), beta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: A430088C08Rik

基因 ID: 18970 | 基因类型: protein coding

关于 Polb

功能概要

Predicted to enable several functions, including DNA-directed DNA Polymerase activity; damaged DNA binding activity; and microtubule binding activity. Acts upstream of or within several processes, including base-excision repair, gap-filling; immune system development; and intrinsic apoptotic signaling pathway in response to DNA damage. Predicted to be located in cytoplasm and spindle microtubule. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in early conceptus; hemolymphoid system; muscle tissue; nervous system; and sensory organ. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human POLB (DNA Polymerase beta). [provided by Alliance of Genome Resources, Apr 2022]

Polb 基因产物(1)

mRNA Protein Name
NM_011130.2 NP_035260.1 DNA polymerase beta
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apoptotic process IMP
IMP: 通过突变表型推断
24388753 MGI
acts upstream of or within base-excision repair, gap-filling IMP
IMP: 通过突变表型推断
15177179 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: 通过突变表型推断
24388753 MGI
acts upstream of or within immunoglobulin heavy chain V-D-J recombination IMP
IMP: 通过突变表型推断
24388753 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
27996060 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
24388753 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
10197627 MGI
acts upstream of or within lymph node development IMP
IMP: 通过突变表型推断
24388753 MGI
acts upstream of or within neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
15485914 MGI
acts upstream of or within salivary gland morphogenesis IMP
IMP: 通过突变表型推断
24388753 MGI
acts upstream of or within somatic diversification of immunoglobulins IMP
IMP: 通过突变表型推断
24388753 MGI
acts upstream of or within somatic hypermutation of immunoglobulin genes IMP
IMP: 通过突变表型推断
24388753 MGI
acts upstream of or within spleen development IMP
IMP: 通过突变表型推断
24388753 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

DNA polymerase beta

Pol beta

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10818 POLB Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS10830 POLG2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19369 Polb Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25861 Polb Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Polb NCBI NCBI:5423
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