2. Gene
  3. ELF4 - E74 like ETS transcription factor 4 Gene

ELF4 - E74 like ETS transcription factor 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：E74 样 ETS 转录因子 4

种属: Homo sapiens

同用名: MEF; ELFR; AIFBL2

基因 ID: 2000 | 基因类型: protein coding

关于 ELF4

Cytogenetic location: Xq26.1 Genomic coordinates (GRCh38): X:130,063,955-130,111,927 (from NCBI)

This gene has 3 transcripts (splice variants), 94 orthologues, 28 paralogues and is associated with 63 phenotypes. Broad expression in bone marrow (RPKM 18.8), placenta (RPKM 12.9) and 21 other tissues.

功能概要

该基因编码的蛋白质是一种转录激活因子，可结合并激活 CSF2、IL3、IL8 和 PRF1 基因的启动子。编码的蛋白质参与自然杀伤细胞的发育和功能、先天免疫以及幼稚 CD8+ 细胞中细胞周期停滞的诱导。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2010 年 1 月]

The protein encoded by this gene is a transcriptional activator that binds and activates the promoters of the CSF2, IL3, IL8, and PRF1 genes. The encoded protein is involved in natural killer cell development and function, innate immunity, and induction of cell cycle arrest in naive CD8+ cells. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]

ELF4 基因产物(2)

mRNA Protein Name
NM_001127197.2 NP_001120669.1 ETS-related transcription factor Elf-4
NM_001421.4 NP_001412.1 ETS-related transcription factor Elf-4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
14625302 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
14625302 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10207087 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
34326534 GOA
involved in negative regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
34326534 GOA
involved in negative regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
34326534 GOA
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
35266071 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
8895518 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8895518 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in PML body IDA
IDA: 通过直接分析推断
14970218 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ELF4 蛋白结构

Elf-1_N

Elf-1_N: Transcription factor protein N terminal (1 - 104)

Ets

Ets: Ets-domain (209 - 292)

  • 0
  • 200
  • 400
  • 600
  • 663 a.a.
蛋白主名 其他名称

ETS-related transcription factor Elf-4

E74-like factor 4 (ets domain transcription factor)

关联疾病

疾病名称 别名
Autoinflammatory Syndrome, Familial, X-Linked, Behcet-Like 2

Dex

AIFBL2

Deficiency In Elf4, X-Linked
Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia

IGHD3

Ighd Iii

Fleisher Syndrome

Growth Hormone Deficiency With Hypogammaglobulinemia, X-Linked

Hypogammaglobulinemia And Isolated Growth Hormone Deficiency, X-Linked

Agammaglobulinemia And Isolated Growth Hormone Deficiency, X-Linked

Short Stature Due To Isolated Growth Hormone Deficiency With X-Linked Hypogammaglobulinemia

Growth Hormone Deficiency, Isolated, 3, With Agammaglobulinemia

Agammaglobulinemia And Isolated Growth Hormone Deficiency

Isolated Growth Hormone Deficiency Type 3

X-Linked Hypogammaglobulinemia And Isolated Growth Hormone Deficiency
Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-150612 (R)-STU104 Inhibitor 99.91% 否
HY-150612S (R)-STU104-d6 99.90% 否
HY-RS04301 ELF4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21334 Elf4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27853 Elf4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ELF4 VGNC VGNC:61808
Mus musculus ELF4 MGD MGI:1928377
Rattus norvegicus ELF4 RGD RGD:1560743
Canis familiaris ELF4 VGNC VGNC:40301
Bos taurus ELF4 VGNC VGNC:28429
Macaca mulatta ELF4 VGNC VGNC:72208
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